| 词条 | Perkin reaction |
| 释义 |
| verifiedrevid = 342064841 | Type = Condensation reaction | NamedAfter = William Henry Perkin | Section2 = {{Reactionbox Identifiers | RSC_ontology_id_verified = rsccite | RSC_ontology_id = 0000003 | Reaction = {{Reactionbox Reaction | Reactant1 = Aromatic aldehyde | Reactant2 = Aliphatic Acid anhydride | Reagent1 = Alkali salt of the acid | Product1 = Cinnamic acid derivatives }} The Perkin reaction is an organic reaction developed by English chemist William Henry Perkin that is used to make cinnamic acids. It gives an α,β-unsaturated aromatic acid by the aldol condensation of an aromatic aldehyde and an acid anhydride, in the presence of an alkali salt of the acid.[1][2] The alkali salt acts as a base catalyst, and other bases can be used instead.[3] Several reviews have been written.[4][5][6] Reaction mechanismThe above mechanism is not universally accepted, as several other versions exist, including decarboxylation without acetic group transfer.[7] Applications
See also
References1. ^{{cite journal|author=Perkin, W. H.|journal=Journal of the Chemical Society|year=1868|volume=21|pages= 53–61|doi=10.1039/js8682100053|title= On the artificial production of coumarin and formation of its homologues|url=https://babel.hathitrust.org/cgi/pt?id=mdp.39015077817479;view=1up;seq=65 }} {{DEFAULTSORT:Perkin Reaction}}2. ^{{cite journal|author=Perkin, W. H.|journal=Journal of the Chemical Society|year=1877|volume=32|pages= 660–674|doi=10.1039/js8773200660|title= On some hydrocarbons obtained from the homologues of cinnamic acid; and on anethol and its homologues|url=https://babel.hathitrust.org/cgi/pt?id=mdp.39015077817446;view=1up;seq=1444}} 3. ^{{cite journal |title= The nature of the catalyst in the Perkin condensation |first1= J. F. J. |last1= Dippy |first2= R. M. |last2= Evans |journal= J. Org. Chem. |year= 1950 |volume= 15 |issue= 3 |pages= 451–456 |doi= 10.1021/jo01149a001 }} 4. ^{{cite journal|author=Johnson, J. R.|journal=Org. React.|year=1942|volume=1|pages= 210|doi=10.1002/0471264180.or001.08|title=The Perkin Reaction and Related Reactions|isbn=0471264180}} 5. ^House, H. O. (1972) Modern Synthetic Reactions, W. A. Benjamin, Menlo Park, California, 2nd ed, pp. 660–663 6. ^{{cite journal|author=Rosen, T.|journal=Compr. Org. Synth.|year=1991|volume=2|pages= 395–408|doi=10.1016/B978-0-08-052349-1.00034-2|title=The Perkin Reaction|isbn=978-0-08-052349-1}} 7. ^Bansal, Raj K. (1998) Organic Reaction Mechanisms, Tata McGraw Hill, 3rd Edition , pp. 199–201, {{ISBN|9780470858585}} {{DOI|10.1002/0470858583}}. 8. ^{{cite journal|last1=Solladié|first1=Guy|last2=Pasturel-Jacopé|first2=Yacine|last3=Maignan|first3=Jean|title=A re-investigation of resveratrol synthesis by Perkins reaction. Application to the synthesis of aryl cinnamic acids|journal=Tetrahedron|volume=59|issue=18|year=2003|pages=3315–3321|issn=0040-4020|doi=10.1016/S0040-4020(03)00405-8}} 2 : Condensation reactions|Name reactions |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。