| 词条 | Bupicomide |
| 释义 |
| ImageFile = Bupicomide.svg | ImageSize = 200px | IUPACName = 5-Butyl-2-pyridinecarboxamide | OtherNames = Sch-10595; Fusaramide[1] |Section1={{Chembox Identifiers | CASNo = 22632-06-0 | CASNo_Ref = {{cascite|correct|}} | UNII = 0X3H76N0HY | PubChem = 31447 | ChemSpiderID = 29167 | ChEMBL = 2106646 | SMILES = O=C(c1ncc(cc1)CCCC)N | InChI = 1/C10H14N2O/c1-2-3-4-8-5-6-9(10(11)13)12-7-8/h5-7H,2-4H2,1H3,(H2,11,13) | InChIKey = VKSPIPWLHGKJQO-UHFFFAOYAT | StdInChI = 1S/C10H14N2O/c1-2-3-4-8-5-6-9(10(11)13)12-7-8/h5-7H,2-4H2,1H3,(H2,11,13) | StdInChIKey = VKSPIPWLHGKJQO-UHFFFAOYSA-N |Section2={{Chembox Properties | C=10 | H=14 | N=2 | O=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Bupicomide is a chemical compound created and manufactured by Lanospharma Laboratories Company, Ltd. It is used experimentally as a beta blocker{{citation needed|date=February 2012}} and clinically as a strong vasodilator with the noted side effects of reduced systolic, diastolic and mean arterial pressure.[2][3][4] SynthesisAs the result of the screening program examining microbial fermentation products for pharmacological activity (other than antibiotic activity), fusaric acid was isolated from Fusarium oxysporum following the discovery that extracts were potent inhibitors of DBH, and thus interfered with the biosynthesis of the pressor neurohormone, norepinephrine. To refine this lead, amidation via the acid chloride was carried out to give antihypertensive analog bupicomide.[5] References1. ^Bupicomide, Chemical Book {{Monoamine metabolism modulators}}{{aromatic-stub}}2. ^{{cite journal |pmid=782220 |year=1976 |last1=Chrysant |first1=SG |last2=Adamopoulos |first2=P |last3=Tsuchiya |first3=M |last4=Frohlich |first4=ED |title=Systemic and renal hemodynamic effects of bupicomide: A new vasodilator |volume=92 |issue=3 |pages=335–9 |journal=American Heart Journal |doi=10.1016/s0002-8703(76)80114-7}} 3. ^{{cite journal |pmid=1097150 |year=1975 |last1=Velasco |first1=M |last2=Gilbert |first2=CA |last3=Rutledge |first3=CO |last4=McNay |first4=JL |title=Antihypertensive effect of a dopamine beta hydroxylase inhibitor, bupicomide: A comparison with hydralazine |volume=18 |issue=2 |pages=145–53 |journal=Clinical Pharmacology and Therapeutics}} 4. ^{{cite journal|title=Physiologic mechanisms of bupicomide- and hydralazine-induced increase in plasma renin activity in hypertensive patients.|journal=Mayo Clinic Proceedings|volume=52|issue=7|pages=430–2|pmid=875465|year=1977|last1=Velasco|first1=M.|last2=McNay|first2=J. L.}} 5. ^{{Cite patent|DE|2217084}} 3 : Beta blockers|Pyridines|Carboxamides |
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