| 词条 | Calcium buffering |
| 释义 |
The regulation of free calcium is of particular importance in excitable cells like cardiomyocytes and neurons. Within these cells, many intracellular proteins can act as calcium buffers. In cardiac muscle cells, the most important buffers within the cytoplasm include troponin C, SERCA, calmodulin, and myosin, while the most important within calcium buffer within the sarcoplasmic reticulum is calsequestrin.[2][3] Clinical significanceAlterations in calcium buffering within the cytosol have been implicated in the tendency to arrhythmias (abnormal cardiac rhythms) in some genetic mutations known to cause hypertrophic cardiomyopathy.[4] Genetic mutations affecting calsequestrin are responsible for an autosomal recessive form of catecholaminergic polymorphic ventricular tachycardia, an inherited cardiac condition that can lead to sudden death.[5] Calcium buffering within atrial myocytes is affected by ageing in large animal models, elevating sarcoplasmic reticulum calcium content, which could potentially contribute towards a tendency to atrial fibrillation.[6] See also{{Portal|Neuroscience}}
References1. ^{{cite journal|last1=Gilabert|first1=JA|year=2012|title=Cytoplasmic calcium buffering|journal=Adv. Exp. Med. Biol.|volume=740|pages=483–98|doi=10.1007/978-94-007-2888-2_20|pmid=22453955}} 2. ^1 2 {{Cite book|url=https://www.worldcat.org/oclc/47659382|title=Excitation-contraction coupling and cardiac contractile force|last=M.|first=Bers, D.|date=2001|publisher=Kluwer Academic Publishers|isbn=9780792371588|edition=2nd|location=Dordrecht|oclc=47659382}} 3. ^{{Cite journal|last=Briston|first=Sarah J.|last2=Dibb|first2=Katharine M.|last3=Solaro|first3=R. John|last4=Eisner|first4=David A.|last5=Trafford|first5=Andrew W.|date=2014-11-01|title=Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes|journal=Cardiovascular Research|volume=104|issue=2|pages=347–354|doi=10.1093/cvr/cvu201|issn=1755-3245|pmc=4240166|pmid=25183792}} 4. ^{{Cite journal|last=Schober|first=Tilmann|last2=Huke|first2=Sabine|last3=Venkataraman|first3=Raghav|last4=Gryshchenko|first4=Oleksiy|last5=Kryshtal|first5=Dmytro|last6=Hwang|first6=Hyun Seok|last7=Baudenbacher|first7=Franz J.|last8=Knollmann|first8=Björn C.|date=2012-07-06|title=Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia|journal=Circulation Research|volume=111|issue=2|pages=170–179|doi=10.1161/CIRCRESAHA.112.270041|issn=1524-4571|pmc=3393041|pmid=22647877}} 5. ^{{Cite journal|last=Lieve|first=Krystien V.|last2=van der Werf|first2=Christian|last3=Wilde|first3=Arthur A.|date=2016-05-25|title=Catecholaminergic Polymorphic Ventricular Tachycardia|journal=Circulation Journal: Official Journal of the Japanese Circulation Society|volume=80|issue=6|pages=1285–1291|doi=10.1253/circj.CJ-16-0326|issn=1347-4820|pmid=27180891}} 6. ^{{Cite journal|last=Clarke|first=Jessica D.|last2=Caldwell|first2=Jessica L.|last3=Pearman|first3=Charles M.|last4=Eisner|first4=David A.|last5=Trafford|first5=Andrew W.|last6=Dibb|first6=Katharine M.|date=2017-10-01|title=Increased Ca buffering underpins remodelling of Ca(2+) handling in old sheep atrial myocytes|journal=The Journal of Physiology|volume=595|issue=19|pages=6263–6279|doi=10.1113/JP274053|issn=1469-7793|pmc=5621500|pmid=28752958}} 1 : Calcium signaling |
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