“PFP (enzyme)”的意思、由来-开放百科全书

Diphosphate—fructose-6-phosphate 1-phosphotransferase also known as PFP is an enzyme of carbohydrate metabolism in plants and some bacteria. The enzyme ({{EC_number|2.7.1.90}}) catalyses the reversible interconversion of fructose 6-phosphate and fructose 1,6-bisphosphate using inorganic pyrophosphate as the phosphoryl donor:

In plants, the PFP is located in the cytosol of the cell and is strongly activated by the signal molecule fructose 2,6-bisphosphate.

PFP is an exclusively cytosolic enzyme that catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate in the glycolytic direction, and the de-phosphorylation of fructose-1,6-bisphosphate to fructose-6-phosphate in the gluconeogenic reaction. Reeves^[2] first isolated PFP from Entamoeba histolytica, a lower eukaryote. The first plant PFP isolated was from the leaves of pineapples by Carnal and Black^[3] and it has since been isolated from a variety of plant species and tissues.^[4]

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is diphosphate:D-fructose-6-phosphate 1-phosphotransferase. Other names in common use include:

See also

References

1. ^{{PDB|6PFK}}; {{cite journal |vauthors=Schirmer T, Evans PR | title = Structural basis of the allosteric behaviour of phosphofructokinase | journal = Nature | volume = 343 | issue = 6254 | pages = 140–5 |date=January 1990 | pmid = 2136935 | doi = 10.1038/343140a0 | url = }}
2. ^{{cite journal |vauthors=Reeves RE, South DJ, Blytt HJ, Warren LG | title = Pyrophosphate:D-fructose 6-phosphate 1-phosphotransferase. A new enzyme with the glycolytic function of 6-phosphofructokinase | journal = J. Biol. Chem. | volume = 249 | issue = 24 | pages = 7737–41 |date=December 1974 | pmid = 4372217 | doi = | url = }}
3. ^{{cite journal |vauthors=Carnal NW, Black CC | title = Pyrophosphate-dependent 6-phosphofructokinase, a new glycolytic enzyme in pineapple leaves | journal = Biochem. Biophys. Res. Commun. | volume = 86 | issue = 1 | pages = 20–6 |date=January 1979 | pmid = 219853 | doi = 10.1016/0006-291X(79)90376-0| url = }}
4. ^{{cite journal | author = Stitt M|date=June 1990 | title = Fructose-2,6-Bisphosphate as a Regulatory Molecule in Plants | journal = Annual Review of Plant Physiology and Plant Molecular Biology | volume = 41 | pages = 153–185 | doi = 10.1146/annurev.pp.41.060190.001101 }}

Nomenclature

See also

References

Further reading