| 词条 | Carboxycyclophosphamide |
| 释义 |
| ImageFile = Carboxycyclophosphamide.svg | ImageSize = 200 | ImageAlt = Carboxycyclophosphamide chemical structure | IUPACName = 3-({amino[bis(2-chloroethyl)amino]phosphoryl}oxy)propanoic acid | OtherNames = Carboxyphosphamide | Section1 = {{Chembox Identifiers | CASNo = 22788-18-7 | PubChem = 31515 | SMILES = C(COP(=O)(N)N(CCCl)CCCl)C(=O)O | ChemSpiderID = 29229 | InChI = 1/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(10,14)15-6-1-7(12)13/h1-6H2,(H2,10,14)(H,12,13) | InChIKey = QLAKAJLYYGOZQL-UHFFFAOYAS | StdInChI = 1S/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(10,14)15-6-1-7(12)13/h1-6H2,(H2,10,14)(H,12,13) | StdInChIKey = QLAKAJLYYGOZQL-UHFFFAOYSA-N | Section2 = {{Chembox Properties | Formula = C7H15Cl2N2O4P | MolarMass = 293.084762 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. In the metabolic pathway of cyclophosphamide inactivation it first metabolizes to 4-hydroxycyclophosphamide, then partially tautomerizes into aldophosphamide. Aldophosphamide then, in turn, is oxidized into carboxycyclophosphamide by the enzyme ALDH (aldehyde dehydrogenase).[1] References1. ^[https://www.ncbi.nlm.nih.gov/pubmed/1610409 Dockham PA, Lee MO, Sladek NE. Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde. Biochem Pharmacol. 1992 Jun 9;43(11):2453-69] {{organic-compound-stub}} 4 : Human drug metabolites|Nitrogen mustards|Phosphorodiamidates|Chloroethyl compounds |
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