| 词条 | CBiPES |
| 释义 |
| IUPAC_name = N-(4'-cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)ethanesulfonamide | image = CBiPES_structure.png | width = 200 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 3372 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 856702-40-4 | ATC_prefix = none | ATC_suffix = | PubChem = 9864510 | DrugBank = | ChemSpiderID = 8040202 | StdInChI = 1S/C21H19N3O2S/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19/h3-13,15H,2,16H2,1H3 | StdInChIKey = HDVYXILCBYGKGU-UHFFFAOYSA-N | C=21 | H=19 | N=3 | O=2 | S=1 | molecular_weight = 377.459 g/mol | smiles = N#Cc1ccc(cc1)-c(ccc2)cc2N(S(=O)(=O)CC)Cc3cccnc3 }}CBiPES is a drug used in scientific research that acts as a selective positive allosteric modulator for the metabotropic glutamate receptor group II subtype mGluR2. It has potentially antipsychotic effects in animal models, and is used for researching the role of mGluR2 receptors in schizophrenia and related disorders.[1][2][3] References1. ^{{Cite journal | last1 = Johnson | first1 = M. P. | last2 = Barda | first2 = D. | last3 = Britton | first3 = T. C. | last4 = Emkey | first4 = R. | last5 = Hornback | first5 = W. J. | last6 = Jagdmann | first6 = G. E. | last7 = McKinzie | first7 = D. L. | last8 = Nisenbaum | first8 = E. S. | last9 = Tizzano | first9 = J. P. | doi = 10.1007/s00213-004-2099-9 | last10 = Schoepp | first10 = D. D. | title = Metabotropic glutamate 2 receptor potentiators: Receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s) | journal = Psychopharmacology | volume = 179 | issue = 1 | pages = 271–283 | year = 2005 | pmid = 15717213 | pmc = }} {{Metabotropic glutamate receptor modulators}}{{nervous-system-drug-stub}}2. ^{{Cite journal | last1 = Fell | first1 = M. J. | last2 = Katner | first2 = J. S. | last3 = Johnson | first3 = B. G. | last4 = Khilevich | first4 = A. | last5 = Schkeryantz | first5 = J. M. | last6 = Perry | first6 = K. W. | last7 = Svensson | first7 = K. A. | doi = 10.1016/j.neuropharm.2009.11.014 | title = Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge | journal = Neuropharmacology | volume = 58 | issue = 3 | pages = 632–639 | year = 2010 | pmid = 19951716 | pmc = }} 3. ^{{Cite journal | last1 = Sanger | first1 = H. | last2 = Hanna | first2 = L. | last3 = Colvin | first3 = E. M. | last4 = Grubisha | first4 = O. | last5 = Ursu | first5 = D. | last6 = Heinz | first6 = B. A. | last7 = Findlay | first7 = J. D. | last8 = Vivier | first8 = R. G. | last9 = Sher | first9 = E. | last10 = Lodge | first10 = D. | last11 = Monn | first11 = J. A. | last12 = Broad | first12 = L. M. | title = Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR | doi = 10.1016/j.neuropharm.2012.05.023 | journal = Neuropharmacology | volume = 66 | pages = 264–273 | year = 2012 | pmid = 22659090 | pmc = }} 3 : Antipsychotics|MGlu2 receptor agonists|MGlu3 receptor agonists |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。