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词条 CBX7 (gene)
释义

  1. Model organisms

  2. References

  3. Further reading

Chromobox homolog 7 is a protein that in humans is encoded by the CBX7 gene.[1] The loss of CBX7 gene expression has been shown to correlate with a malignant form of thyroid cancer.[2]

Model organisms

Model organisms have been used in the study of CBX7 function. A conditional knockout mouse line, called Cbx7tm1a(KOMP)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[11][12][13] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty six tests were carried out and three significant phenotypes were reported. Homozygous mutant female adults showed a decreased response to stress-induced hyperthermia and had an increased red blood cell count. Animals of both sex had an integument phenotype when tail epidermis was examined.[7]

References

1. ^{{cite web | title = Chromobox homolog 7| url = https://www.ncbi.nlm.nih.gov/gene/23492| accessdate = 2011-12-06}}
2. ^{{Cite journal | last1 = Pallante | first1 = P. | last2 = Federico | first2 = A. | last3 = Berlingieri | first3 = M. T. | last4 = Bianco | first4 = M. | last5 = Ferraro | first5 = A. | last6 = Forzati | first6 = F. | last7 = Iaccarino | first7 = A. | last8 = Russo | first8 = M. | last9 = Pierantoni | first9 = G. M. | last10 = Leone | doi = 10.1158/0008-5472.CAN-08-0695 | first10 = V. | last11 = Sacchetti | first11 = S. | last12 = Troncone | first12 = G. | last13 = Santoro | first13 = M. | last14 = Fusco | first14 = A. | title = Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer | journal = Cancer Research | volume = 68 | issue = 16 | pages = 6770–6778 | year = 2008 | pmid = 18701502 | pmc = }}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MACK/stress-induced-hyperthermia/ |title=Body temperature data for Cbx7 |publisher=Wellcome Trust Sanger Institute}}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MACK/haematology-cbc/ |title=Haematology data for Cbx7 |publisher=Wellcome Trust Sanger Institute}}
5. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MACK/salmonella-challenge/ |title=Salmonella infection data for Cbx7 |publisher=Wellcome Trust Sanger Institute}}
6. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MACK/citrobacter-challenge/ |title=Citrobacter infection data for Cbx7 |publisher=Wellcome Trust Sanger Institute}}
7. ^1 2 {{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}
8. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
9. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Cbx7 |title=International Knockout Mouse Consortium}}
10. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4363230 |title=Mouse Genome Informatics}}
11. ^{{Cite journal| last1 = Skarnes |first1 =W. C.| doi = 10.1038/nature10163 | last2 = Rosen | first2 = B.| last3 = West | first3 = A. P.| last4 = Koutsourakis | first4 = M.| last5 = Bushell | first5 = W.| last6 = Iyer | first6 = V.| last7 = Mujica | first7 = A. O.| last8 = Thomas | first8 = M.| last9 = Harrow | first9 = J.| last10 = Cox | first10 = T.| last11 = Jackson | first11 = D.| last12 = Severin | first12 = J.| last13 = Biggs | first13 = P.| last14 = Fu | first14 = J.| last15 = Nefedov | first15 = M.| last16 = De Jong | first16 = P. J.| last17 = Stewart | first17 = A. F.| last18 = Bradley | first18 = A. | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | year = 2011 | pmid = 21677750 | pmc =3572410 }}
12. ^{{cite journal |author=Dolgin E |title=Mouse library set to be knockout |journal=Nature |volume=474 |issue=7351 |pages=262–3 |date=June 2011 |pmid=21677718 |doi=10.1038/474262a }}
13. ^{{cite journal |vauthors=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |date=January 2007 |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }}
14. ^{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}}

Further reading

  • {{Cite journal

| last1 = Yap | first1 = K. L.
| last2 = Li | first2 = S.
| last3 = Muñoz-Cabello | first3 = A. M.
| last4 = Raguz | first4 = S.
| last5 = Zeng | first5 = L.
| last6 = Mujtaba | first6 = S.
| last7 = Gil | first7 = J. S.
| last8 = Walsh | first8 = M. J.
| last9 = Zhou | first9 = M. M.
| doi = 10.1016/j.molcel.2010.03.021
| title = Molecular Interplay of the Non-coding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a
| journal = Molecular Cell
| volume = 38
| issue = 5
| pages = 662–674
| year = 2010
| pmid = 20541999
| pmc =2886305
}}
  • {{Cite journal

| last1 = Federico | first1 = A.
| last2 = Pallante | first2 = P.
| last3 = Bianco | first3 = M.
| last4 = Ferraro | first4 = A.
| last5 = Esposito | first5 = F.
| last6 = Monti | first6 = M.
| last7 = Cozzolino | first7 = M.
| last8 = Keller | first8 = S.
| last9 = Fedele | first9 = M.
| last10 = Leone
| doi = 10.1158/0008-5472.CAN-09-1542 | first10 = V.
| last11 = Troncone | first11 = G.
| last12 = Chiariotti | first12 = L.
| last13 = Pucci | first13 = P.
| last14 = Fusco | first14 = A.
| title = Chromobox Protein Homologue 7 Protein, with Decreased Expression in Human Carcinomas, Positively Regulates E-Cadherin Expression by Interacting with the Histone Deacetylase 2 Protein
| journal = Cancer Research
| volume = 69
| issue = 17
| pages = 7079–7087
| year = 2009
| pmid = 19706751
| pmc =
}}
  • {{Cite journal

| last1 = Pallante | first1 = P.
| last2 = Terracciano | first2 = L.
| last3 = Carafa | first3 = V.
| last4 = Schneider | first4 = S.
| last5 = Zlobec | first5 = I.
| last6 = Lugli | first6 = A.
| last7 = Bianco | first7 = M.
| last8 = Ferraro | first8 = A.
| last9 = Sacchetti | first9 = S.
| last10 = Troncone
| doi = 10.1016/j.ejca.2010.05.011 | first10 = G.
| last11 = Fusco | first11 = A.
| last12 = Tornillo | first12 = L.
| title = The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients
| journal = European Journal of Cancer
| volume = 46
| issue = 12
| pages = 2304–2313
| year = 2010
| pmid = 20542683
| pmc =
}}
  • {{Cite journal

| last1 = Zhang | first1 = X. W.
| last2 = Zhang | first2 = L.
| last3 = Qin | first3 = W.
| last4 = Yao | first4 = X. H.
| last5 = Zheng | first5 = L. Z.
| last6 = Liu | first6 = X.
| last7 = Li | first7 = J.
| last8 = Guo | first8 = W. J.
| doi = 10.1186/1756-9966-29-114
| title = Oncogenic role of the chromobox protein CBX7 in gastric cancer
| journal = Journal of Experimental & Clinical Cancer Research
| volume = 29
| issue = 1
| pages = 114
| year = 2010
| pmid = 20723236
| pmc =2933612
}}{{refend}}{{gene-22-stub}}

2 : Human proteins|Genes mutated in mice
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