“CD8+ cell noncytotoxic anti-HIV response”的意思、由来-开放百科全书

The presence of a CD8+ cell noncytotoxic anti-HIV response (CNAR) was first reported in 1986 by researchers in the laboratory of Dr. Jay Levy at the University of California San Francisco (UCSF).^[2] It was recognized that CD8+ cells from HIV-infected individuals can suppress HIV replication without directly killing the infected cells.

CNAR was originally hypothesized to be mediated by a CD8+ cell anti-HIV factor (CAF). It is now known that CNAR is mediated by multiple secreted proteins or 'soluble factors', including beta-chemokines (MIP-1 alpha, MIP-1 beta, and RANTES)^[3] and type I interferons (interferon alpha and interferon beta).^[4]

References

1. ^{{citation | last=Levy | first=Jay A. | year=2007 | title=HIV and the pathogenesis of AIDS | edition=3 | publisher=Wiley-Blackwell | isbn=978-1-55581-393-2 | page=209 | url=https://books.google.com/books?id=ii-pri5nWAkC }}
2. ^{{cite journal|vauthors=Walker CM, Moody DJ, Stites DP, Levy JA | title=CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication | journal=Science | year= 1986 | volume= 234 | issue= 4783 | pages= 1563–6 | pmid=2431484 | doi= 10.1126/science.2431484| pmc= | url= | bibcode=1986Sci...234.1563W }}
3. ^{{Cite journal|last=Cocchi|first=Fiorenza|last2=DeVico|first2=Anthony L.|last3=Garzino-Demo|first3=Alfredo|last4=Arya|first4=Suresh K.|last5=Gallo|first5=Robert C.|last6=Lusso|first6=Paolo|date=1995-12-15|title=Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells|url=http://science.sciencemag.org/content/270/5243/1811|journal=Science|language=en|volume=270|issue=5243|pages=1811–1815|doi=10.1126/science.270.5243.1811|issn=0036-8075|pmid=8525373|bibcode=1995Sci...270.1811C}}
4. ^{{Cite journal|last=Killian|first=M. Scott|last2=Teque|first2=Fernando|last3=Walker|first3=Robert L.|last4=Meltzer|first4=Paul S.|last5=Killian|first5=J. Keith|date=November 2013|title=CD8+ Lymphocytes Suppress Human Immunodeficiency Virus 1 Replication by Secreting Type I Interferons|url=|journal=Journal of Interferon & Cytokine Research|language=en|volume=33|issue=11|pages=632–645|doi=10.1089/jir.2012.0067|issn=1079-9907|pmc=3814821|pmid=23402527|via=}}