| 词条 | Cepharanthine |
| 释义 |
| drug_name = | IUPAC_name = | image = Cepharanthine-.png | alt = | caption = | tradename = | Drugs.com = {{Drugs.com|international|cepharanthine}} | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = | ATCvet = | ATC_prefix = none | ATC_suffix = | PubChem = 10206 | ChEMBL = 449782 | ChemSpiderID = 9791 | DrugBank = | synonyms = Cepharantin, O-Methylcepharanoline | C = 37 | H = 38 | N = 2 | O = 6 | molecular_weight = 606.70742 g/mol | smiles = CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3 | StdInChI = 1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1 | StdInChIKey = YVPXVXANRNDGTA-WDYNHAJCSA-N }}Cepharanthine is an antiinflammatory and antineoplastic compound isolated from Stephania.[1] Due to these modalities, it has been shown effective against HTLV in lab research. [2] Additionally, it has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. [3] References1. ^{{Cite journal | last1 = Huang | first1 = H. | last2 = Hu | first2 = G. | last3 = Wang | first3 = C. | last4 = Xu | first4 = H. | last5 = Chen | first5 = X. | last6 = Qian | first6 = A. | title = Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models | doi = 10.1007/s10753-013-9734-8 | journal = Inflammation | year = 2013 | pmid = 24045962 | pmc = | volume=37 | issue=1 | pages=235–46}} {{Anti-inflammatory products}}{{musculoskeletal-drug-stub}}{{antineoplastic-drug-stub}}2. ^{{cite journal | pmid = 22753721 | volume=32 | title=Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative | year=2012 | journal=Anticancer Res. | pages=2639–45 | last1 = Toyama | first1 = M | last2 = Hamasaki | first2 = T | last3 = Uto | first3 = T | last4 = Aoyama | first4 = H | last5 = Okamoto | first5 = M | last6 = Hashmoto | first6 = Y | last7 = Baba | first7 = M}} 3. ^{{cite journal | pmid = 21602589 | volume=63 | title=Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions | journal=Pharmacol Rep | pages=337-47 | last1 = Rogosnitzky | first1 = M | last2 = Danks | first2 = R}} 2 : Alkaloids|Anti-inflammatory agents |
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