| 词条 | Cerlapirdine |
| 释义 |
| IUPAC_name = N,N-dimethyl-3-[(3-naphthalen-1-ylsulfonyl-2H-indazol-5-yl)oxy]propan-1-amine | image = Cerlapirdine.svg | CAS_number = 925448-93-7 | CAS_supplemental = 925447-04-7 (hydrochloride) | ChEMBL = 2103880 | ATC_prefix = none | ATC_suffix = | KEGG = D10099 | KEGG_Ref = {{keggcite|correct|kegg}} | PubChem = 16071605 | ChemSpiderID = 17231095 | C = 22 | H = 23 | N = 3 | O = 3 | S = 1 | molecular_weight = 409.501 g/mol | smiles = CN(C)CCCOc4ccc3[nH]nc(S(=O)(=O)c1cccc2ccccc12)c3c4 | StdInChI = 1S/C22H23N3O3S/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24) | StdInChIKey = NXQGEDVQXVTCDA-UHFFFAOYSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_category = | legal_status = Investigational | routes_of_administration = }}Cerlapirdine (USAN; SAM-531, WAY-262,531, PF-05212365) is a drug which was under development by Wyeth/Pfizer for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia.[1] In a phase II clinical trial it demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events,[2] but no further development has occurred since 2011.[3] It exerts its effects by acting as a selective 5-HT6 receptor antagonist.[1] See also
References1. ^1 {{cite journal |vauthors=Codony X, Vela JM, Ramírez MJ | title = 5-HT(6) receptor and cognition | journal = Current Opinion in Pharmacology | volume = 11 | issue = 1 | pages = 94–100 |date=February 2011 | pmid = 21330210 | doi = 10.1016/j.coph.2011.01.004 | url = http://linkinghub.elsevier.com/retrieve/pii/S1471-4892(11)00005-1| hdl = 10171/18451 }} {{Nootropics}}{{Antidementia}}{{Serotonergics}}2. ^{{cite book | author = Franco Borsini | title = International review of neurobiology: Pharmacology of 5-HT6 receptors. Part 2 | url = https://books.google.com/books?id=E41bjxtgyzoC&pg=PA5 | accessdate = 25 October 2011 | year = 2011 | publisher = Academic Press | isbn = 978-0-12-385902-0 | page=5}} 3. ^Drug Profile: Cerlapirdine 2 : Amines|Nootropics |
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