| 词条 | Chalconoid |
| 释义 |
Chalconoids Greek: χαλκός khalkós, "copper", due to its color), also known as chalcones, are natural phenols related to chalcone. They form the central core for a variety of important biological compounds. They show antibacterial, antifungal, antitumor and anti-inflammatory properties. Some chalconoids demonstrated the ability to block voltage-dependent potassium channels.[1] Chalcones are also natural aromatase inhibitors.[2] Chalcones are aromatic ketones with two phenyl rings that are also intermediates in the synthesis of many biological compounds. The closure of hydroxychalcones causes the formation of the flavonoid structure. Flavonoids are substances in the plant secondary metabolism with an array of biological activities. Chalconoids are also intermediates in the Auwers synthesis of flavones. Chemical propertiesChalcones have two absorption maxima at 280 nm and 340 nm.[3] Biosynthesis and metabolismChalcone synthase is an enzyme responsible for the production of chalconoids in plants.
Related compounds
References1. ^{{Cite journal| last1 = Yarishkin | first1 = O. V.| last2 = Ryu | first2 = H. W.| last3 = Park | first3 = J. Y. | last4 = Yang | first4 = M. S.| last5 = Hong | first5 = S. G.| last6 = Park | first6 = K. H.| DOI = 10.1016/j.bmcl.2007.10.114| title = Sulfonate chalcone as new class voltage-dependent K+ channel blocker| journal = Bioorganic & Medicinal Chemistry Letters| volume = 18| issue = 1| pages = 137–140|year = 2008|pmid = 18032041| pmc =}} 2. ^{{cite journal |DOI=10.1016/S0024-3205(00)00974-7 |title=Chalcones are potent inhibitors of aromatase and 17β-hydroxysteroid dehydrogenase activities |year=2001 |last1=Le Bail |first1=Jean-Christophe |last2=Pouget |first2=Christelle |last3=Fagnere |first3=Catherine |last4=Basly |first4=Jean-Philippe |last5=Chulia |first5=Albert-Jose |last6=Habrioux |first6=Gerard |journal=Life Sciences |volume=68 |issue=7 |pages=751–61 |pmid=11205867}} 3. ^Photochemistry of chalcone and the application of chalcone-derivatives in photo-alignment layer of liquid crystal display. Dong-mee Song, Kyoung-hoon Jung, Ji-hye Moon and Dong-myung Shin, Optical Materials, 2002, volume 21, pages 667–671, {{doi|10.1016/S0925-3467(02)00220-3}} External links
| url = http://www.reference.md/files/D047/mD047188.html | title = Chalcones | publisher = Reference.MD }}{{Natural phenol}}{{chalconoid}} 1 : Chalconoids |
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