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词条 Charles Lee (scientist)
释义

  1. Education

  2. Work

  3. Major research publications

  4. Awards / Appointments

  5. References

{{Infobox scientist
|name = Charles Lee
|image = 찰스리.PNG
|imagesize =
|caption =
|birth_name =
|birth_date = {{birth date and age|1969|4|1}}
|birth_place = Seoul, Korea
|residence = United States of America
|nationality = Canada
|field = Human genomics, cytogenetics, pathology
|work_institution = The Jackson Laboratory for Genomic Medicine
|alma_mater = University of Alberta
|doctoral_advisor = Dr. C.C. Lin
|doctoral_students=
}}

Charles Lee is Director and Professor of The Jackson Laboratory for Genomic Medicine and a board certified clinical cytogeneticist who has an active research program in the identification and characterization of structural genomic variants using advanced technology platforms. His laboratory was the first to describe genome-wide structural genomic variants (in the form of copy number variants (CNVs)) among humans[1] with the subsequent development of two human CNV maps[2][3] that are now actively used in the diagnoses of array based genetic tests. Dr. Lee is also a Distinguished Professor at Ewha Woman's University and the current President of the Human Genome Organisation (HUGO).

Education

  • 1990: BS in Genetics, University of Alberta
  • 1993: MS in Experimental Pathology, University of Alberta
  • 1996: PhD in Medical Sciences, University of Alberta
  • 1996-1999: NSERC Fellow, University of Cambridge, UK
  • 1999-2001: Clinical Cytogenetics Fellow, Harvard Medical School

Work

Positions held

  • 2001-2003: Instructor, Pathology, Harvard Medical School
  • 2003-2008: Assistant Professor, Pathology, Harvard Medical School
  • 2008-2013: Associate Professor, Pathology, Harvard Medical School
  • 2013: Director & Professor, The Jackson Laboratory for Genomic Medicine

Major research publications

  • 1993: Lee C, Sasi R, Lin CC. Interstitial localization of telomeric DNA sequences in the Indian muntjac chromosomes: further evidence for tandem chromosome fusions in the karyotypic evolution of the Asian muntjacs. Cytogenet. Cell Genet.. 1993; 63: 156-9[1]
  • 1997 : Lee C, Wevrick R, Fisher RB, Ferguson-Smith MA, Lin CC. Human centromeric DNAs. Hum Genet. 1997; 100: 291-304[2]
  • 2004: Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C. Detection of large-scale variation in the human genome. Nat Genet. 2004; 36: 949-51[3]
  • 2006: Redon R, Ishikawa S, Fitch KR, Feuk L, Perry G, Andrews TD, Fiegler H, ... , Tyler-Smith C, Carter NP, Aburatani H, Jones KW, Scherer SW, Hurles ME, Lee C. Global variation in copy number in the human genome. Nature. 2006; 444: 444-54[4] Co-senior authors
  • 2007: Perry GH, Dominy NJ, Claw KG, Lee AS, Fiegler H, Redon R, Werner J, Villanea FA, Mountain JL, Misra R, Carter NP, Stone AC, Lee C. Diet and the evolution of human gene copy number variation. Nat Genet. 2007; 39: 1256-60[5] Co-senior authors
  • 2007: Lee C, Iafrate AJ, Brothman AR. Copy number variations and clinical cytogenetic diagnosis of constitutional disorders. Nat Genet. 2007; 39: S48-S54[6]
  • 2008: Perry GH, Ben-Dor A, Tsalenko A, Sampas N, Rodriguez-Revenga L, Tran CW, Scheffer A, Steinfeld I, Tsang P, Yamada NA, Park HS, Kim JI, Seo JS, Yakhini Z, Laderman S, Bruhn L, Lee C. The fine-scale and complex architecture of human copy number variation. Am J Hum Genet. 2008; 82: 685-95[7]
  • 2009: Kim JI, Ju Y, Park H, Kim S, Lee S, Yi JH, ... , Park WY, Kim H, Church GM, Lee C, Kingsmore SF, Seo JS. A highly annotated whole genome sequence of a Korean individual. Nature. 2009; 460: 1011-5[8]
  • 2010: Conrad D, Pinto D, Redon R, Feuk L, Gokcumen O, Zhang Y, ... , Tyler-Smith C, Carter NP, Scherer SW, Hurles ME, Lee C. Common copy number variation in the human genome: mechanism, selection and disease association. Nature. 2010; 464: 704-12[9] Co-senior authors
  • 2011: Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, ... , Eichler EE, Gerstein MB, Hurles ME, McCarroll SA, Korbel, JO, Lee C. Mapping copy number variation by population-scale genome sequencing. Nature. 2011; 470: 59-65[10] Co-senior authors
  • 2012: Brown, KH, Dobrinski KP, Lee AS, Gokcumen O, Mills RE, Shi X, Chong WW, Chen JY, Yoo P, David S, Peterson SM, Raj T, Choy KW, Stranger B, Williamson RE, Zon LI, Freeman JL, Lee C. Extensive genetic diversity and sub-structuring among zebrafish strains revealed through copy number variant analysis. Proc Natl Acad Sci USA 2012; 109: 529-534[11]
  • 2013: Gokcumen O, Tischler V, Tica J, Zhu Q, Iskow RC, Lee E, Fritz MH, Langdon A, Stutz AM, Pavlidis P, Benes V, Mills RE, Park PJ, Korbel JO, Lee C. Primate genome architecture influences structural variation mechanisms and functional consequences. Proc Natl Acad Sci USA 2013; 110: 15764-9[12] Co-senior author
  • 2015: Sudmant PH, Rausch T, Gardner EJ, Handsaker RE, Abzov A, ... , Mills RE, Gerstein M, Bashir A, Stegle O, Devine SE, Lee C, Eichler EE, Korbel JO. An integrated map of structural variation in 2,504 numan genomes. Nature 2015; 526: 75-81[13]
  • 2017: Zhu Q, High FA, Zhang C, Cereira E, Russell M, Longoni M, Ryan M, Mil-homens A, Bellfy L, Coletti C, Bhayani P, Jila R, Donahoe PK, Lee C. Systematic analysis of copy number variation associated with congenital diaphragmatic hernia. Proc Natl Acad Sci USA 2018; 115: 5247-5252[14]

Awards / Appointments

  • 2007: American Association for Cancer Research [https://www.aacr.org/Research/Awards/PAGES/TEAM-SCIENCE-AWARD-___8470D6.ASPX#.W065vqOZOHo Team Award]
  • 2008: Ho-am Prize in Medicine
  • 2010: [https://pediatrics.duke.edu/sites/pediatrics.duke.edu/files/field/attachments/2010_spring_alumni.pdf George W. Brumley Jr, MD Memorial Award] (Duke University)
  • 2011-: Honorary Professor, Chinese University of Hong Kong
  • 2012: Vandenberghe Chair Award (Katholic University of Leuven, Belgium)
  • 2012: [https://web.archive.org/web/20141231002800/http://www.hugo-international.org/chen_awardrecipients_2012.php Chen Investigator Award] (Human Genome Organisation - HUGO)
  • 2012: Fellow, American Association for the Advancement of Science (AAAS)
  • 2013-5: Distinguished Visiting Professor, Seoul National University, Korea
  • 2014: Thomson Reuters Citation Laureate
  • 2015-: Distinguished EWHA Professor, Ewha Womans University, Korea
  • 2017-: President, Human Genome Organisation
  • 2018: [https://www.ualberta.ca/alumni/recognition University of Alberta Distinguished Alumni Award]

References

1. ^{{cite journal|title=Interstitial localization of telomeric DNA sequences in the Indian muntjac chromosomes: further evidence for tandem chromosome fusions in the karyotypic evolution of the Asian muntjacs|journal=Cytogenet. Cell Genet.|date=1993|volume=63|issue=3|pages=156–159|doi=10.1159/000133525|pmid=8485991|last1=Lee|first1=C.|last2=Sasi|first2=R.|last3=Lin|first3=C.C.}}
2. ^{{cite journal|title=Human centromeric DNAs|journal=Human Genetics|date=1997|volume=100|issue=3–4|pages=291–304|doi=10.1007/s004390050508|last1=Lee|first1=C.|last2=Wevrick|first2=R.|last3=Fisher|first3=R. B.|last4=Ferguson-Smith|first4=M. A.|last5=Lin|first5=C. C.}}
3. ^1 {{cite journal|title=Detection of large-scale variation in the human genome|journal=Nat. Genet.|date=2004|volume=36|pages=949–951|doi=10.1038/ng1416|pmid=15286789|issue=9 | last1 = Iafrate | first1 = AJ | last2 = Feuk | first2 = L | last3 = Rivera | first3 = MN |display-authors=et al}}
4. ^1 {{cite journal|title=Global variation in copy number in the human genome|journal=Nature|volume=444|date=2006|pages=444–454|bibcode=2006Natur.444..444R|doi=10.1038/nature05329|pmid=17122850|issue=7118|pmc=2669898 | last1 = Redon | first1 = R | last2 = Ishikawa | first2 = S | last3 = Fitch | first3 = KR |display-authors=et al}}
5. ^{{cite journal|title=Diet and the evolution of human gene copy number variation|journal=Nat. Genet.|date=2007|volume=39|issue=10|pages=1256–1260|doi=10.1038/ng2123|pmid=17828263|pmc=2377015 | last1 = Perry | first1 = GH | last2 = Dominy | first2 = NJ | last3 = Claw | first3 = KG |display-authors=et al}}
6. ^{{cite journal|title=Copy number variations and clinical cytogenetic diagnosis of constitutional disorders|journal=Nat. Genet.|date=2007|volume=39|issue=7s|pages=S48–54|doi=10.1038/ng2092|pmid=17597782|last1=Lee|first1=Charles|last2=Iafrate|first2=A John|last3=Brothman|first3=Arthur R.}}
7. ^{{cite journal|title=The fine-scale and complex architecture of human copy number variation|journal=Am J Hum Genet|date=2008|volume=82|pages=685–695}}
8. ^{{cite journal|title=A highly annotated whole genome sequence of a Korean individual|journal=Nature|date=2009|volume=460|issue=7258|pages=1011–1015|doi=10.1038/nature08211 |bibcode = 2009Natur.460.1011K|pmid=19587683|pmc=2860965 | last1 = Kim | first1 = JI | last2 = Ju | first2 = YS | last3 = Park | first3 = H | last4 = Kim | first4 = S | last5 = Lee | first5 = S | last6 = Yi | first6 = JH | last7 = Mudge | first7 = J | last8 = Miller | first8 = NA | last9 = Hong | first9 = D | last10 = Bell | first10 = CJ | last11 = Kim | first11 = HS | last12 = Chung | first12 = IS | last13 = Lee | first13 = WC | last14 = Lee | first14 = JS | last15 = Seo | first15 = SH | last16 = Yun | first16 = JY | last17 = Woo | first17 = HN | last18 = Lee | first18 = H | last19 = Suh | first19 = D | last20 = Lee | first20 = S | last21 = Kim | first21 = HJ | last22 = Yavartanoo | first22 = M | last23 = Kwak | first23 = M | last24 = Zheng | first24 = Y | last25 = Lee | first25 = MK | last26 = Park | first26 = H | last27 = Kim | first27 = JY | last28 = Gokcumen | first28 = O | last29 = Mills | first29 = RE | last30 = Zaranek | first30 = AW | last31 = Thakuria | first31 = J | last32 = Wu | first32 = X | last33 = Kim | first33 = RW | last34 = Huntley | first34 = JJ | last35 = Luo | first35 = S | last36 = Schroth | first36 = GP | last37 = Wu | first37 = TD | last38 = Kim | first38 = H | last39 = Yang | first39 = KS | last40 = Park | first40 = WY | last41 = Kim | first41 = H | last42 = Church | first42 = GM | last43 = Lee | first43 = C | last44 = Kingsmore | first44 = SF | last45 = Seo | first45 = JS}}
9. ^1 {{cite journal|title=Common copy number variation in the human genome: mechanism, selection and disease association|journal=Nature|date=2010|volume=464|issue=7289|pages=704–712|doi=10.1038/nature08516|pmid=19812545|bibcode = 2010Natur.464..704. |pmc=3330748|last1=Conrad|first1=Donald F.|last2=Pinto|first2=Dalila|last3=Redon|first3=Richard|last4=Feuk|first4=Lars|last5=Gokcumen|first5=Omer|last6=Zhang|first6=Yujun|last7=Aerts|first7=Jan|last8=Andrews|first8=T. Daniel|last9=Barnes|first9=Chris|last10=Campbell|first10=Peter|last11=Fitzgerald|first11=Tomas|last12=Hu|first12=Min|last13=Ihm|first13=Chun Hwa|last14=Kristiansson|first14=Kati|last15=MacArthur|first15=Daniel G.|last16=MacDonald|first16=Jeffrey R.|last17=Onyiah|first17=Ifejinelo|last18=Pang|first18=Andy Wing Chun|last19=Robson|first19=Sam|last20=Stirrups|first20=Kathy|last21=Valsesia|first21=Armand|last22=Walter|first22=Klaudia|last23=Wei|first23=John|last24=Tyler-Smith|first24=Chris|last25=Carter|first25=Nigel P.|last26=Lee|first26=Charles|last27=Scherer|first27=Stephen W.|last28=Hurles|first28=Matthew E.}}
10. ^{{cite journal|title=Mapping copy number variation by population-scale genome sequencing|journal=Nature|volume=470|issue=7332|date=2011|pages=59–65|bibcode= 2011Natur.470...59.|doi=10.1038/nature09708|pmid=21293372|pmc=3077050 | last1 = Mills | first1 = RE | last2 = Walter | first2 = K | last3 = Stewart | first3 = C |display-authors=et al}}
11. ^{{cite journal|title=Extensive genetic diversity and sub-structuring among zebrafish strains revealed through copy number variant analysis|journal=Proc Natl Acad Sci USA|volume=109|issue=2|date=2012|pages=529–534|doi=10.1073/pnas.1112163109 |pmid=22203992|pmc=3258620|bibcode = 2012PNAS..109..529B |last1=Brown|first1=Kim H.|last2=Dobrinski|first2=Kimberly P.|last3=Lee|first3=Arthur S.|last4=Gokcumen|first4=Omer|last5=Mills|first5=Ryan E.|last6=Shi|first6=Xinghua|last7=Chong|first7=Wilson W. S.|last8=Chen|first8=Jin Yun Helen|last9=Yoo|first9=Paulo|last10=David|first10=Sthuthi|last11=Peterson|first11=Samuel M.|last12=Raj|first12=Towfique|last13=Choy|first13=Kwong Wai|last14=Stranger|first14=Barbara E.|last15=Williamson|first15=Robin E.|last16=Zon|first16=Leonard I.|last17=Freeman|first17=Jennifer L.|last18=Lee|first18=Charles}}
12. ^{{cite journal|title=Primate genome architecture influences structural variation mechanisms and functional consequences|journal=Proc Natl Acad Sci USA|volume=110|issue=39|date=2013|pages=15764–15769|doi=10.1073/pnas.1305904110 |bibcode = 2013PNAS..11015764G|pmid=24014587|pmc=3785719 | last1 = Gokcumen | first1 = O | last2 = Tischler | first2 = V | last3 = Tica | first3 = J | last4 = Zhu | first4 = Q | last5 = Iskow | first5 = RC | last6 = Lee | first6 = E | last7 = Fritz | first7 = MH | last8 = Langdon | first8 = A | last9 = Stütz | first9 = AM | last10 = Pavlidis | first10 = P | last11 = Benes | first11 = V | last12 = Mills | first12 = RE | last13 = Park | first13 = PJ | last14 = Lee | first14 = C | last15 = Korbel | first15 = JO}}
13. ^{{Cite journal|last=Sudmant|first=Peter H.|last2=Rausch|first2=Tobias|last3=Gardner|first3=Eugene J.|last4=Handsaker|first4=Robert E.|last5=Abyzov|first5=Alexej|last6=Huddleston|first6=John|last7=Zhang|first7=Yan|last8=Ye|first8=Kai|last9=Jun|first9=Goo|date=2015-10-01|title=An integrated map of structural variation in 2,504 human genomes|journal=Nature|volume=526|issue=7571|pages=75–81|doi=10.1038/nature15394|issn=0028-0836|pmc=4617611|pmid=26432246|bibcode=2015Natur.526...75.}}
14. ^{{Cite journal|last=Zhu|first=Qihui|last2=High|first2=Frances A.|last3=Zhang|first3=Chengsheng|last4=Cerveira|first4=Eliza|last5=Russell|first5=Meaghan K.|last6=Longoni|first6=Mauro|last7=Joy|first7=Maliackal P.|last8=Ryan|first8=Mallory|last9=Mil-Homens|first9=Adam|date=2018-05-15|title=Systematic analysis of copy number variation associated with congenital diaphragmatic hernia|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=115|issue=20|pages=5247–5252|doi=10.1073/pnas.1714885115|issn=1091-6490|pmc=5960281|pmid=29712845}}
{{authority control}}{{DEFAULTSORT:Lee, Charles}}

4 : University of Alberta alumni|American pathologists|Living people|1969 births
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