词条 | Chlorosulfolipid |
释义 |
Biosynthesis of danicalipin AInitially, docosanoic acid (behenic acid) (2) is constructed via the fatty acid synthesis pathway. Elovson demonstrated that the C-14 secondary hydroxyl group of molecule 3 was incorporated by oxidation of the fatty acid with molecular oxygen, as opposed to alkene hydration with water. The next step involves the enzyme-mediated transfer of the sulfate group from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to the diol to form molecule 4.[4] Walsh has demonstrated that the halogenation of the unactivated methyl groups is catalyzed by a newly discovered class of α-ketoglutarate-dependent non-heme iron halogenases.[5] The stepwise chlorination occurs via an order-independent radical mechanism.[6] References1. ^Chen, L. L.; Pousada, M.; Haines, T. H. J. Biol. Chem. 1976, 251, 1835–1842 2. ^Elovson, J.; Vagelos, P. R. Proc. Natl. Acad. Sci. U.S.A. 1969, 62, 957–963 3. ^J. L. Chen, P. J. Proteau, M. A. Roberts, W. H. Gerwick, D. L. Slate and R. H. Lee, J. Nat. Prod., 1994, 57, 524–527 4. ^C. L. Mooney and T. H. Haines, Biochemistry, 1973, 12, 4469–4472 5. ^F. H. Vaillancourt, J. Yin and C. T. Walsh, Proc. Natl. Acad. Soc. USA, 2005, 102, 10111–10116 6. ^G. Thomas and E. I. Mercer, Phytochemistry, 1974, 13, 797–805 3 : Lipids|Organochlorides|Anionic surfactants |
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