| 词条 | Chondroitin ABC lyase |
| 释义 |
| Name = Chondroitin ABC lyase | EC_number = 4.2.2.4 | CAS_number = 9024-13-9 | IUBMB_EC_number = 4/2/2/4 | GO_code = | image = | width = | caption = }}Chondroitin ABC lyase ({{EC number|4.2.2.4}}, chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic name chondroitin ABC lyase.[1][2] This enzyme catalyses the following chemical reaction Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups This enzyme acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate. UsesFollowing a spinal cord injury, this enzyme can be used to erode scar tissue that can interfere with regeneration.[3] References1. ^{{cite journal | vauthors = Yamagata T, Saito H, Habuchi O, Suzuki S | title = Purification and properties of bacterial chondroitinases and chondrosulfatases | journal = The Journal of Biological Chemistry | volume = 243 | issue = 7 | pages = 1523–35 | date = April 1968 | pmid = 5647268 }} 2. ^{{cite journal | vauthors = Saito H, Yamagata T, Suzuki S | title = Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates | journal = The Journal of Biological Chemistry | volume = 243 | issue = 7 | pages = 1536–42 | date = April 1968 | pmid = 4231029 }} 3. ^{{cite journal | vauthors = Bartus K, James ND, Didangelos A, Bosch KD, Verhaagen J, Yáñez-Muñoz RJ, Rogers JH, Schneider BL, Muir EM, Bradbury EJ | title = Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury | journal = The Journal of Neuroscience| volume = 34 | issue = 14 | pages = 4822–36 | date = April 2014 | pmid = 24695702 | pmc = 3972714 | doi = 10.1523/JNEUROSCI.4369-13.2014 | lay-summary = https://www.eurekalert.org/pub_releases/2014-04/sfn-gti033114.php | lay-source = Eureka Alert }} External links
2 : EC 4.2.2|Regenerative biomedicine |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。