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词条 Chronic limb threatening ischemia
释义

  1. Types

     Rest pain  Tissue loss 

  2. Diagnosis

  3. Treatment

  4. Research

  5. References

  6. External links

Chronic limb threatening ischemia (CLTI), also referred to as Critical limb ischemia (CLI) and limb threat, is an advanced stage of peripheral artery disease (PAD). It is defined as a triad of ischemic rest pain, arterial insufficiency ulcers, and gangrene. The latter two conditions are jointly referred to as tissue loss, reflecting the development of surface damage to the limb tissue due to the most severe stage of ischemia. Compared to the other manifestation of PAD, intermittent claudication, CLI has a negative prognosis within a year after the initial diagnosis, with 1-year amputation rates of approximately 12% and mortality of 50% at 5 years and 70% at 10 years.[1]

CLI was conceived to identify patients at high-risk for major amputation, but the increasing prevalence of diabetes mellitus has led to a broader conception of limb threat that includes the risk of amputation associated with severely infected and non-healing wounds.[2]

Types

Critical limb ischemia is further subdivided into rest pain and tissue loss:

Rest pain

Rest pain is a continuous burning pain of the lower leg or feet. It begins, or is aggravated, after reclining or elevating the limb and is relieved by sitting or standing. It is more severe than intermittent claudication, which is also a pain in the legs from arterial insufficiency.

Tissue loss

Tissue loss is the development of arterial insufficiency ulcers or gangrene due to peripheral artery disease.

Diagnosis

Critical limb ischaemia is diagnosed by the presence of ischaemic rest pain, arterial insufficiency ulcers and gangrene. Other factors which may point to a diagnosis of critical limb ischaemia are a Buerger's angle of less than 20 degrees during Buerger's test, a capillary refill of more than 15 seconds or diminished or absent pulses.

Critical limb ischaemia is different from acute limb ischaemia. Acute limb ischaemia is a sudden lack of blood flow to the limb, for example caused by an embolus whereas critical limb ischaemia is a late sign of a progressive chronic disease.

Treatment

Treatment mirrors that of other symptoms of peripheral artery disease, and includes modifying risk factors, revascularization via vascular bypass or angioplasty, and in the case of tissue loss, wound debridement.

Research

In 2011 pCMV-vegf165 was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.[3][4]

In 2014, a landmark clinical trial was initiated to better understand the optimal revascularization technique for the treatment of CLI. As of April 2017, the Best Endovascular Versus Best Surgical Therapy for Patients with Critical Limb Ischemia (BEST-CLI) has enrolled nearly half of the 2100 patients needed to complete the trial.[5]A similar study, BASIL 2 (Bypass Versus Angio plasty in Severe Ischaemia of the Leg), is being conducted in the United Kingdom.[6]

References

1. ^{{cite journal |doi=10.1016/j.jvs.2009.08.073 |pmid=20117502 |title=Critical limb ischemia |journal=Journal of Vascular Surgery |volume=51 |issue=1 |pages=230–41 |year=2010 |last1=Varu |first1=Vinit N |last2=Hogg |first2=Melissa E |last3=Kibbe |first3=Melina R }}
2. ^{{cite journal |doi=10.1016/j.jvs.2013.08.003 |pmid=24126108 |title=The Society for Vascular Surgery Lower Extremity Threatened Limb Classification System: Risk stratification based on Wound, Ischemia, and foot Infection (WIfI) |journal=Journal of Vascular Surgery |volume=59 |issue=1 |pages=220–34.e1–2 |year=2014 |last1=Mills |first1=Joseph L |last2=Conte |first2=Michael S |last3=Armstrong |first3=David G |last4=Pomposelli |first4=Frank B |last5=Schanzer |first5=Andres |last6=Sidawy |first6=Anton N |last7=Andros |first7=George |author8=Society for Vascular Surgery Lower Extremity Guidelines Committee }}
3. ^{{cite news|title=Gene Therapy for PAD Approved|url=http://www.dddmag.com/news/2011/12/gene-therapy-pad-approved|accessdate=5 August 2015|date=6 December 2011}}
4. ^{{cite journal |doi=10.1177/1074248415574336 |pmid=25770117 |title=PCMV-vegf165 Intramuscular Gene Transfer is an Effective Method of Treatment for Patients with Chronic Lower Limb Ischemia |journal=Journal of Cardiovascular Pharmacology and Therapeutics |volume=20 |issue=5 |pages=473–82 |year=2015 |last1=Deev |first1=Roman V |last2=Bozo |first2=Ilia Y |last3=Mzhavanadze |first3=Nina D |last4=Voronov |first4=Dmitriy A |last5=Gavrilenko |first5=Aleksandr V |last6=Chervyakov |first6=Yuriy V |last7=Staroverov |first7=Ilia N |last8=Kalinin |first8=Roman E |last9=Shvalb |first9=Pavel G |last10=Isaev |first10=Artur A }}
5. ^{{cite journal |doi=10.1161/JAHA.116.003219 |pmid=27402237 |pmc=5015366 |title=Design and Rationale of the Best Endovascular Versus Best Surgical Therapy for Patients with Critical Limb Ischemia (BEST‐CLI) Trial |journal=Journal of the American Heart Association |volume=5 |issue=7 |pages=e003219 |year=2016 |last1=Menard |first1=Matthew T |last2=Farber |first2=Alik |last3=Assmann |first3=Susan F |last4=Choudhry |first4=Niteesh K |last5=Conte |first5=Michael S |last6=Creager |first6=Mark A |last7=Dake |first7=Michael D |last8=Jaff |first8=Michael R |last9=Kaufman |first9=John A |last10=Powell |first10=Richard J |last11=Reid |first11=Diane M |last12=Siami |first12=Flora Sandra |last13=Sopko |first13=George |last14=White |first14=Christopher J |last15=Rosenfield |first15=Kenneth }}
6. ^{{cite journal |doi=10.1186/s13063-015-1114-2 |pmid=26739146 |pmc=4704263 |title=Bypass versus angio plasty in severe ischaemia of the leg - 2 (BASIL-2) trial: Study protocol for a randomised controlled trial |journal=Trials |volume=17 |pages=11 |year=2016 |last1=Popplewell |first1=Matthew A |last2=Davies |first2=Huw |last3=Jarrett |first3=Hugh |last4=Bate |first4=Gareth |last5=Grant |first5=Margaret |last6=Patel |first6=Smitaa |last7=Mehta |first7=Samir |last8=Andronis |first8=Lazaros |last9=Roberts |first9=Tracy |last10=Deeks |first10=Jon |last11=Bradbury |first11=Andrew }}

External links

  • Cochrane Peripheral Vascular Diseases Review Group
{{Vascular diseases}}

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