| 词条 | Circular RNA (circRNA) databases and resources | |||||||||||||||||||||||||
| 释义 |
In molecular biology, Circular RNAs (circRNAs) refer to a class of circular RNA molecules found across all kingdoms of life.[1][2][3] Studies in 2013 have suggested that circRNAs play important regulatory roles in miRNA activity. Researchers found that CDR1as circRNA acts as a miR-7 super-sponge that contains about 70 target sites from the same miR-7 at the same transcript.[4][5] The other testis-specific circRNA, sex-determining region Y (Sry), also was found as a miR-138 sponge.[6] About-mentioned examples suggesting that miRNA sponge effects achieved by circRNA formation may be a general phenomenon. As miR-7 modulates the expression of several oncogenes, ciRS-7/miR-7 interactions may play an important roles in cancer-related pathways.[7] This Circular RNA (circRNA) databases and resources is a compilation of databases and web portals and servers used for circRNAs.
References1. ^{{cite journal|last=Memczak|first=S|author2=Jens, M |author3=Elefsinioti, A |author4=Torti, F |author5=Krueger, J |author6=Rybak, A |author7=Maier, L |author8=Mackowiak, SD |author9=Gregersen, LH |author10=Munschauer, M |author11=Loewer, A |author12=Ziebold, U |author13=Landthaler, M |author14=Kocks, C |author15=le Noble, F |author16=Rajewsky, N |title=Circular RNAs are a large class of animal RNAs with regulatory potency|journal=Nature|date=Mar 21, 2013|volume=495|issue=7441|pages=333–8|pmid=23446348|bibcode=2013Natur.495..333M|doi=10.1038/nature11928}} 2. ^{{cite journal|last=Hansen|first=TB|author2=Jensen, TI |author3=Clausen, BH |author4=Bramsen, JB |author5=Finsen, B |author6=Damgaard, CK |author7= Kjems, J |title=Natural RNA circles function as efficient microRNA sponges.|journal=Nature|date=Mar 21, 2013|volume=495|issue=7441|pages=384–8|pmid=23446346 |doi=10.1038/nature11993|bibcode = 2013Natur.495..384H }} 3. ^{{cite journal|last=Kosik|first=KS|title=Molecular biology: Circles reshape the RNA world.|journal=Nature|date=Mar 21, 2013|volume=495|issue=7441|pages=322–4|pmid=23446351|doi=10.1038/nature11956|bibcode = 2013Natur.495..322K }} 4. ^{{cite journal|last=Memczak|first=S|author2=Jens, M |author3=Elefsinioti, A |author4=Torti, F |author5=Krueger, J |author6=Rybak, A |author7=Maier, L |author8=Mackowiak, SD |author9=Gregersen, LH |author10=Munschauer, M |author11=Loewer, A |author12=Ziebold, U |author13=Landthaler, M |author14=Kocks, C |author15=le Noble, F |author16=Rajewsky, N |title=Circular RNAs are a large class of animal RNAs with regulatory potency|journal=Nature|date=Mar 21, 2013|volume=495|issue=7441|pages=333–8|pmid=23446348|bibcode=2013Natur.495..333M|doi=10.1038/nature11928}} 5. ^{{cite journal|last=Hansen|first=TB|author2=Jensen, TI |author3=Clausen, BH |author4=Bramsen, JB |author5=Finsen, B |author6=Damgaard, CK |author7= Kjems, J |title=Natural RNA circles function as efficient microRNA sponges.|journal=Nature|date=Mar 21, 2013|volume=495|issue=7441|pages=384–8|pmid=23446346 |doi=10.1038/nature11993|bibcode = 2013Natur.495..384H }} 6. ^{{cite journal|last=Hansen|first=TB|author2=Jensen, TI |author3=Clausen, BH |author4=Bramsen, JB |author5=Finsen, B |author6=Damgaard, CK |author7= Kjems, J |title=Natural RNA circles function as efficient microRNA sponges.|journal=Nature|date=Mar 21, 2013|volume=495|issue=7441|pages=384–8|pmid=23446346 |doi=10.1038/nature11993|bibcode = 2013Natur.495..384H }} 7. ^{{cite journal|last=Hansen|first=TB|author2=Kjems, J |author3=Damgaard, CK |title=Circular RNA and miR-7 in Cancer.|journal=Cancer Research|date=Sep 15, 2013|volume=73|issue=18|pages=5609–12|pmid=24014594|doi=10.1158/0008-5472.CAN-13-1568}} 8. ^{{cite journal|last=Li|first=JH|author2=Liu, S |author3=Zhou, H |author4=Qu, LH |author5= Yang, JH |title=starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.|journal=Nucleic Acids Research|date=Jan 1, 2014|volume=42|issue=1|pages=D92–7|pmid=24297251|doi=10.1093/nar/gkt1248 |pmc=3964941}} 9. ^{{cite journal|last=Memczak|first=S|author2=Jens, M |author3=Elefsinioti, A |author4=Torti, F |author5=Krueger, J |author6=Rybak, A |author7=Maier, L |author8=Mackowiak, SD |author9=Gregersen, LH |author10=Munschauer, M |author11=Loewer, A |author12=Ziebold, U |author13=Landthaler, M |author14=Kocks, C |author15=le Noble, F |author16=Rajewsky, N |title=Circular RNAs are a large class of animal RNAs with regulatory potency|journal=Nature|date=Mar 21, 2013|volume=495|issue=7441|pages=333–8|pmid=23446348|bibcode=2013Natur.495..333M|doi=10.1038/nature11928}} 10. ^{{Cite journal|last=Liu|first=Yu-Chen|last2=Li|first2=Jian-Rong|last3=Sun|first3=Chuan-Hu|last4=Andrews|first4=Erik|last5=Chao|first5=Rou-Fang|last6=Lin|first6=Feng-Mao|last7=Weng|first7=Shun-Long|last8=Hsu|first8=Sheng-Da|last9=Huang|first9=Chieh-Chen|date=2016-01-04|title=CircNet: a database of circular RNAs derived from transcriptome sequencing data|journal=Nucleic Acids Research|volume=44|issue=D1|pages=D209–215|doi=10.1093/nar/gkv940|issn=1362-4962|pmc=4702939|pmid=26450965}} 11. ^{{cite journal|last=Ghosal|first=S|author2=Das, S |author3=Sen, R |author4=Basak, P |author5= Chakrabarti, J |title=Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits.|journal=Frontiers in Genetics|year=2013|volume=4|pages=283|pmid=24339831 |doi=10.3389/fgene.2013.00283 |pmc=3857533}} 12. ^RNA. 2014 Nov;20(11):1666-70. doi: 10.1261/rna.043687.113. Epub 2014 Sep 18.circBase: a database for circular RNAs.Glažar P1, Papavasileiou P1, Rajewsky N2. circbase.org original paper [12] External links
3 : RNA|LncRNA|Biological databases |
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