| 词条 | CJ-033466 |
| 释义 |
| verifiedrevid = 450386388 | IUPAC_name = 5-amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)piperidin-4-yl]methyl]imidazo[1,2-a]pyridine-8-carboxamide | image = CJ-033466.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 10429706 | ChemSpiderID = 8605134 | C=19 | H=28 | Cl=1 | N=5 | O=1 | molecular_weight = 377.910 g/mol | smiles = C3CN(CC(C)C)CCC3CNC(=O)c1cc(Cl)c(N)n(cc2C)c1n2 | StdInChI = 1S/C19H28ClN5O/c1-12(2)10-24-6-4-14(5-7-24)9-22-19(26)15-8-16(20)17(21)25-11-13(3)23-18(15)25/h8,11-12,14H,4-7,9-10,21H2,1-3H3,(H,22,26) | StdInChIKey = ISKHMDNIWXPUGR-UHFFFAOYSA-N | melting_point = | melting_high = }}CJ-033466 is a drug which acts as a potent and selective 5-HT4 serotonin receptor partial agonist. In animal tests it stimulated gastrointestinal motility with 30 times the potency of cisapride, and with lower affinity for the hERG channel.[1][2][3] See also
References1. ^{{cite journal |vauthors=Mikami T, Ochi Y, Suzuki K, Saito T, Sugie Y, Sakakibara M |title=5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=325 |issue=1 |pages=190–9 |date=April 2008 |pmid=18198343 |doi=10.1124/jpet.107.133850 |url=}} {{Propulsives}}{{Serotonergics}}{{gastrointestinal-drug-stub}}2. ^{{cite journal |vauthors=Toga T, Kohmura Y, Kawatsu R |title=The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities |journal=Journal of Pharmacological Sciences |volume=105 |issue=2 |pages=207–10 |date=October 2007 |pmid=17928736 |doi= 10.1254/jphs.sc0070243|url=}} 3. ^{{cite journal |vauthors=Tsuchida Y, Hatao F, Fujisawa M, Murata T, Kaminishi M, Seto Y, Hori M, Ozaki H |title=Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus |journal=Gut |volume=60 |issue=5 |pages=638–47 |date=May 2011 |pmid=21115544 |pmc=3071096 |doi=10.1136/gut.2010.227546 |url=}} 7 : Amines|Carboxamides|Chloroarenes|Imidazoles|Piperidines|Pyridines|Serotonin receptor agonists |
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