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- Historical and political Surname Given name
- Cultural and artistic Surname Given name
- Sport Surname Given name
- Fictional characters
Clayton is both a surname and a given name. Notable people with the name include: Historical and politicalSurname- Augustin Smith Clayton (1783–1839), jurist and politician from Georgia, USA
- Bertram Tracy Clayton (1862–1918), U.S. congressman and army officer killed in World War I
- Christopher Clayton, Royal Navy pilot and admiral
- Christopher Clayton (businessman) (1869–1945), British scientist, industrialist and Conservative politician
- Hilda Clayton (1991–2013), U.S. Army specialist and war photographer
- Henry Clayton (disambiguation), several people
- John Clayton (disambiguation), several people
- John M. Clayton (1796–1856), lawyer, U.S. senator from Delaware and U.S. Secretary of State
- Joseph Clayton (1868–1943), English freelance journalist and biographer
- Joshua Clayton (1744–1798), physician, governor and U.S. senator from Delaware
- Pat Clayton (1896–1962), desert explorer
- Robert Clayton (disambiguation), several people
- Thomas Clayton (1777–1854), lawyer and U.S. senator from Delaware
- Tubby Clayton (1885–1972), Anglican clergyman, army chaplain and founder of Toc H
- Walter F. Clayton (1865–1942), New York politician
- William Clayton (disambiguation), several people
Given name- Clayton Cosgrove (born 1969), New Zealand politician
- Clayton Yeutter (1930–2017), American politician and Secretary of Agriculture
Cultural and artisticSurname- Attitude (rapper) (born 1976, real name Timothy Clayton), American rapper and record producer
- Adam Clayton (born 1960), bassist in U2
- Beth Clayton, American mezzo soprano
- Buck Clayton (1911–1991), American jazz trumpeter
- Doctor Clayton (1898–1947), American blues singer
- Jamie Clayton (born 1978), American actress and model
- Jan Clayton (1917–1983), American actress
- Jay Clayton (critic) (born 1951), literary critic and professor
- Jay Clayton (musician) (born 1941), jazz singer
- Klariza Clayton (born 1989), English actress and singer
- Merry Clayton (born 1948), American singer
- Peter Clayton (1927–1991), BBC jazz presenter, jazz critic, and author
- R. Gilbert Clayton (1922–2013), American film set designer and actor
- Farrah Moan (born 1993, real name Cameron Clayton), American drag queen
Given name- Clayton Chitty (born 1985), Canadian actor and model
- Clayton Hickman (born 1977), British scriptwriter and magazine editor
- Clayton Howard (1934-2017), British make-up artist
- Clayton Moore (1914–1999), American actor best known for playing the Lone Ranger in a television series of the same name
- Clayton Rohner (born 1957), American film and television actor
SportSurname- Adam Clayton (footballer) (born 1989), English footballer
- Andrew Clayton (born 1973), English freestyle swimmer
- Derek Clayton (born 1942), Australian marathon runner
- Jim Clayton (rower) (1911–1992), New Zealand rower
- José Clayton (born 1974), Brazilian-Tunisian footballer
- Josh Clayton (born 1996), Australian rules footballer
- Mark Clayton (American football, born 1961), American football player
- Mark Clayton (American football, born 1982), American football player
- Max Clayton (born 1994), English footballer
- Michael Clayton (American football) (born 1982), American football player
- Royce Clayton (born 1970), Major League Baseball player
- Scott Clayton (born 1959), Australian rules footballer
- Tom Clayton ({{circa|1880}}–1909), Australian jockey
Given name- Clayton Michel Afonso (born 1988), Brazilian footballer
- Clayton Bezerra Leite (born 1987), Brazilian footballer
- Clayton da Silveira da Silva (born 1995), Brazilian footballer
- Clayton Donaldson (born 1984), English-Jamaican footballer
- Clayton Kershaw (born 1988), baseball player
- Clayton Lambert (born 1962), West Indian cricketer
- Clayton Murphy (born 1995), American athlete
- Clayton Nascimento Meireles (born 1989), Brazilian footballer
- Clayton Oliver (born 1997), Australian rules footballer
- Clayton Richard (born 1983), American baseball player
- Clayton Tonnemaker (1928–1996), American football player
Fictional characters- Michael Clayton, title character in 2007 Oscar-nominated film of the same name
- William Cecil Clayton, character in Tarzan of the Apes
- Clayton Farlow, oil baron in the American television series Dallas
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