| 词条 | Clifford Tabin |
| 释义 |
| name = Cliff Tabin | birth_name = Clifford James Tabin | image = Professor_Clifford_Tabin_ForMemRS.jpg | image_size = | alt = | caption = Cliff Tabin in 2014, portrait via the Royal Society | birth_date = {{Birth date and age|1954|01|19}}[1] | birth_place = Glencoe, Illinois | other_names = | residence = | citizenship = | nationality = | fields = {{Plainlist|
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| thesis_title = Activation of the c-Ha-ras Oncogene | thesis_url = http://www.worldcat.org/oclc/13089293 | thesis_year = 1984 | doctoral_advisor = Robert Weinberg | academic_advisors = | doctoral_students = | notable_students = | known_for = Sonic hedgehog[3] | influences = {{Plainlist|
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| footnotes = | spouse = | parent = Julius Tabin[6] | children = }}Professor Clifford James Tabin (born 1954) is Chairman of the Department of Genetics at Harvard Medical School.[9][10][11] EducationTabin was educated at the University of Chicago where he was awarded a Bachelor of Science degree in Physics in 1976.[9] He went on to graduate school at Massachusetts Institute of Technology (MIT) and was awarded a PhD in 1984 for work on the regulation of gene expression in the Ras subfamily of oncogenes supervised by Robert Weinberg based in the MIT Department of Biology.[12] In Weinberg's lab, Tabin constructed murine leukemia virus,[4] the first recombinant retrovirus that could be used as a eukaryotic vector.[10] CareerFollowing his PhD, Tabin did postdoctoral research with Douglas A. Melton at Harvard University, then moved to Massachusetts General Hospital where he worked on the molecular biology of limb development. He was appointed to the faculty in the Department of Genetics at Harvard Medical School in 1989, and promoted to Full Professor in 1997 and Chairman of the Department in January 2007.[13][14] Research{{As of|2014}} Tabin's research[15][16][17] investigates the genetic regulation of vertebrate development,[18][19][20] combining classical methods of experimental embryology with modern molecular and genetic techniques for regulating gene expression during embryogenesis.[21][22][23]Previously Tabin has worked on retroviruses, homeobox genes, oncogenes, developmental biology and evolution. Early in his research he investigated limb regeneration in the salamander, and described the expression of retinoic acid receptor and Hox genes in the blastema. Comparative studies by Ann Burke[24][25] in his lab showed that differences in boundaries of Hox gene expression correlated with differences in skeletal morphology.[26][27][28][29] The Tabin laboratory adjoins the laboratory of Connie Cepko.[30] Awards and honoursTabin was elected a Foreign Member of the Royal Society (ForMemRS) in 2014. His nomination reads: {{centered pull quote|Tabin has made fundamental discoveries on embryonic development and evolution. A critical turning point in the history of developmental biology was the identification of the first known secreted morphogen, Sonic hedgehog. He clarified how morphogens like Shh orchestrate formation of the embryo, elucidating why the heart is located on the left and not the right side of the body and explaining why the thumb is different from the little finger. This provided critical insight into the origins of human congenital malformations. He has also solved important evolutionary riddles including the causes of variations in beak shape in Darwin's finches.[31]}} Tabin has also been awarded the Edwin Conklin Medal in 2012,[6] the March of Dimes Prize in Developmental Biology jointly with Philip A. Beachy in 2008[7] and the NAS Award in Molecular Biology in 1999. He was elected a member of the National Academy of Sciences in 2007[8] and the American Academy of Arts and Sciences in 2000. Personal lifeTabin is the son of Julius Tabin,[9][10][32] a nuclear physicist who worked with Enrico Fermi on the Manhattan Project in Los Alamos National Laboratory in New Mexico during World War II. His has a brother, Geoff Tabin, and two children. Tabin appears as himself in a BBC Horizon programme titled Hopeful Monsters.[33] References1. ^[https://drb.hms.harvard.edu/node/88 Cliff Tabin], Harvard Medical School {{FRS 2014}}{{Authority control}}{{DEFAULTSORT:Tabin, Clifford John}}2. ^{{Cite journal| doi = 10.1038/384176a0| title = Biochemical evidence that Patched is the Hedgehog receptor| journal = Nature| volume = 384| issue = 6605| pages = 176–9| year = 1996| last1 = Marigo | first1 = V. | last2 = Davey | first2 = R. A. | last3 = Zuo | first3 = Y. | last4 = Cunningham | first4 = J. M. | last5 = Tabin | first5 = C. J. | pmid=8906794}} 3. ^{{Cite journal | doi = 10.1016/0092-8674(93)90626-2| title = Sonic hedgehog mediates the polarizing activity of the ZPA| journal = Cell| volume = 75| issue = 7| pages = 1401–16| year = 1993| last1 = Riddle | first1 = R. D. | last2 = Johnson | first2 = R. L. | last3 = Laufer | first3 = E. | last4 = Tabin | first4 = C. | pmid=8269518}} 4. ^1 {{Cite journal | pmid = 6283119| pmc = 256749| year = 1982| author1 = Goff| first1 = S. P.| title = Transfection of fibroblasts by cloned Abelson murine leukemia virus DNA and recovery of transmissible virus by recombination with helper virus| journal = Journal of Virology| volume = 41| issue = 1| pages = 271–85| last2 = Tabin| first2 = C. J.| authorlink2 = Clifford Tabin| last3 = Wang| first3 = J. Y.| last4 = Weinberg| first4 = R| authorlink4 = Robert Weinberg| last5 = Baltimore| first5 = D| authorlink5 = David Baltimore}} 5. ^{{Cite journal | pmid = 3015593| pmc = 1166933| year = 1986| author1 = Harvey| first1 = R. P.| title = Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products| journal = The EMBO Journal| volume = 5| issue = 6| pages = 1237–44| last2 = Tabin| first2 = C. J.| last3 = Melton| first3 = D. A.| doi = 10.1002/j.1460-2075.1986.tb04352.x}} 6. ^1 Clifford Tabin Awarded Conklin Medal, Society for Developmental Biology 7. ^1 {{Cite journal| author = Anon | doi = 10.1038/nrg2863| pmid = 18504824| title = An Interview With... Cliff Tabin| journal = Nature Reviews Genetics| volume = 9| issue = 6| pages = 420| year = 2008}} 8. ^1 {{cite web|url =http://www.nasonline.org/member-directory/members/20014920.html|title =Clifford J. Tabin, Harvard University|publisher =National Academy of Sciences|deadurl =yes|archiveurl =https://web.archive.org/web/20141014164137/http://www.nasonline.org/member-directory/members/20014920.html|archivedate =2014-10-14|df =}} 9. ^1 2 3 4 {{Cite journal | last1 = Mossman | first1 = K. | title = Profile of Clifford Tabin | doi = 10.1073/pnas.0903946106 | journal = Proceedings of the National Academy of Sciences | volume = 106 | issue = 21 | pages = 8407–8409 | year = 2009 | pmid = 19458049 | pmc =2688980 }} 10. ^1 2 {{Cite journal| pmid = 19557679| year = 2009| author1 = Tabin| first1 = C| title = Molecular tools, classic questions - an interview with Clifford Tabin. Interviewed by Richardson, Michael K| journal = The International Journal of Developmental Biology| volume = 53| issue = 5–6| pages = 725–31| doi = 10.1387/ijdb.072575mr}} 11. ^{{YouTube|id=f5FAIhZMhGA|title=CSHL Keynote: Dr. Clifford Tabin, Harvard Medical School}}, Cold Spring Harbor Laboratory 12. ^{{cite thesis |degree=PhD |first=Clifford James|last=Tabin |title=Activation of the c-Ha-ras Oncogene |publisher=Massachusetts Institute of Technology |date=1984 |url=http://www.worldcat.org/oclc/13089293|oclc=13089293}} 13. ^Cliff Tabin molbio seminar, Princeton University 14. ^{{Cite journal | doi = 10.1073/pnas.0504834102| title = The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb| journal = Proceedings of the National Academy of Sciences| volume = 102| issue = 31| pages = 10898–903| year = 2005| last1 = Harfe | first1 = B. D.| last2 = McManus | first2 = M. T.| last3 = Mansfield | first3 = J. H.| last4 = Hornstein | first4 = E.| last5 = Tabin | first5 = C. J. | pmid=16040801 | pmc=1182454}} 15. ^{{Scopus|id=7005560284}} 16. ^{{AcademicSearch|302665}} 17. ^[https://scholar.google.co.uk/scholar?q=clifford+tabin Clifford Tabin publications], Google Scholar 18. ^{{Cite journal | doi = 10.1038/297474a0| title = Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene| journal = Nature| volume = 297| issue = 5866| pages = 474–8| year = 1982| last1 = Parada | first1 = L. F. | last2 = Tabin | first2 = C. J. | last3 = Shih | first3 = C. | last4 = Weinberg | first4 = R. A. | pmid=6283357}} 19. ^{{Cite journal | doi = 10.1038/384176a0| title = Biochemical evidence that Patched is the Hedgehog receptor| journal = Nature| volume = 384| issue = 6605| pages = 176–9| year = 1996| last1 = Marigo | first1 = V. | last2 = Davey | first2 = R. A. | last3 = Zuo | first3 = Y. | last4 = Cunningham | first4 = J. M. | last5 = Tabin | first5 = C. J. | pmid=8906794}} 20. ^{{Cite journal | doi = 10.1016/S0070-2153(03)53002-2| pmid = 12509125| title = 1 Developmental roles and clinical significance of Hedgehog signaling| journal = Current Topics in Developmental Biology| volume = 53| pages = 1–114| year = 2003| last1 = McMahon | first1 = A. P. | last2 = Ingham | first2 = P. W. | last3 = Tabin | first3 = C. J. | isbn = 9780121531539}} 21. ^{{Cite journal | doi = 10.1016/0092-8674(91)90612-3| pmid = 1677315| title = Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development| journal = Cell| volume = 66| issue = 2| pages = 199–217| year = 1991| last1 = Tabin | first1 = C. J. }} 22. ^{{Cite journal| pmid = 9323126| year = 1997| author1 = Johnson| first1 = R. L.| title = Molecular models for vertebrate limb development| journal = Cell| volume = 90| issue = 6| pages = 979–90| last2 = Tabin| first2 = C. J.| doi=10.1016/s0092-8674(00)80364-5}} 23. ^{{Cite journal | doi = 10.1126/science.273.5275.613| title = Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein| journal = Science| volume = 273| issue = 5275| pages = 613–22| year = 1996| last1 = Vortkamp | first1 = A.| last2 = Lee | first2 = K.| last3 = Lanske | first3 = B.| last4 = Segre | first4 = G. V.| last5 = Kronenberg | first5 = H. M.| last6 = Tabin | first6 = C. J. | pmid=8662546}} 24. ^{{Cite journal | pmid = 7768176| year = 1995| author1 = Burke| first1 = A. C.| title = Hox genes and the evolution of vertebrate axial morphology| journal = Development| volume = 121| issue = 2| pages = 333–46| last2 = Nelson| first2 = C. E.| last3 = Morgan| first3 = B. A.| last4 = Tabin| first4 = C}} 25. ^{{Cite journal | pmid = 8812121| year = 1996| author1 = Burke| first1 = A. C.| title = Virally mediated misexpression of Hoxc-6 in the cervical mesoderm results in spinal nerve truncations| journal = Developmental Biology| volume = 178| issue = 1| pages = 192–7| last2 = Tabin| first2 = C. J.| doi = 10.1006/dbio.1996.0210}} 26. ^1 {{Cite journal | doi = 10.1038/nrc1859|title=Milestone 17: (1979) First human oncogene: An important difference|author=Patrick Goymer|journal=Milestones in Cancer|publisher=Nature|date=April 2006|url=http://www.nature.com/milestones/milecancer/full/milecancer17.html}} 27. ^{{Cite journal | pmid = 7902151| year = 1993| author1 = Morgan| first1 = B. A.| title = The role of homeobox genes in limb development| journal = Current Opinion in Genetics & Development| volume = 3| issue = 4| pages = 668–74| last2 = Tabin| first2 = C. J.| doi=10.1016/0959-437x(93)90105-x}} 28. ^{{Cite journal | doi = 10.1016/j.cell.2006.09.018| pmid = 17018270| title = The Key to Left-Right Asymmetry| journal = Cell| volume = 127| issue = 1| pages = 27–32| year = 2006| last1 = Tabin | first1 = C. J. }} 29. ^{{Cite journal| pmid = 9708733| doi = 10.1016/S0092-8674(00)81474-9| year = 1998| author1 = Logan| first1 = M| title = The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals| journal = Cell| volume = 94| issue = 3| pages = 307–17| last2 = Pagán-Westphal| first2 = S. M.| last3 = Smith| first3 = D. M.| last4 = Paganessi| first4 = L| last5 = Tabin| first5 = C. J.| authorlink5 = Clifford Tabin}} 30. ^Profile of Constance L. Cepko, Ph.D, BioTechniques Vol. 36, No. 5, 2004-05-05, p. 737 31. ^1 {{cite web |url=https://royalsociety.org/people/fellowship/2014/clifford-tabin/ |title=Professor Clifford Tabin ForMemRS |publisher=The Royal Society |archivedate=2014-05-02 |archiveurl=https://web.archive.org/web/20140502073210/https://royalsociety.org/people/fellowship/2014/clifford-tabin/ |location=London |deadurl=yes |df= }} 32. ^Julius Tabin Obituary (1919-2012) Physicist helped develop atom bomb, Chicago Tribune, 2012-09-02 33. ^{{IMDb name | id= 5522676 }} 8 : 1954 births|Living people|University of Chicago alumni|Massachusetts Institute of Technology alumni|American geneticists|Harvard Medical School faculty|Foreign Members of the Royal Society|Members of the United States National Academy of Sciences |
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