| 词条 | Clitocine |
| 释义 |
| ImageFile = Clitocine.svg | ImageSize = 200px | ImageAlt = | IUPACName = (2R,3R,4S,5R)-2-[(6-Amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol | OtherNames = |Section1={{Chembox Identifiers | CASNo = 105798-74-1 | PubChem = 129111 | ChemSpiderID = 114380 | SMILES = C1=NC(=C(C(=N1)N[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)[N+](=O)[O-])N}} |Section2={{Chembox Properties | C=9 | H=13 | N=5 | O=6 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Clitocine is a mushroom nucleoside isolate with anticancer activity in vitro.[1][2][3] References1. ^{{cite journal|title=Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis|pmid=18222036 | doi=10.1016/j.canlet.2007.12.013 | volume=262|issue=2|date=April 2008|pages=190–200}} {{organic-compound-stub}}2. ^{{cite journal|title=Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line|pmid=22927901 | doi=10.1371/journal.pone.0040720 | pmc=3425549|volume=7|issue=8|year=2012|journal=PLoS ONE|pages=e40720}} 3. ^{{cite journal|title=Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo|pmid=24563182 | doi=10.1007/s10495-014-0969-0 | volume=19|issue=5|date=May 2014|journal=Apoptosis|pages=871–82}} 1 : Nucleosides |
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