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词条 CLUAP1
释义

  1. Model organisms

  2. References

  3. External links

  4. Further reading

{{Infobox_gene}}Clusterin associated protein 1, also known as CLUAP1, is a human gene.[1]

Model organisms

Model organisms have been used in the study of CLUAP1 function. A conditional knockout mouse line, called Cluap1tm1a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty six tests were carried out on mutant mice and four significant abnormalities were observed.[5] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; both sexes had decreased IgG1 levels while males also displayed abnormal spine curvature resulting in kyphosis.[5]

References

1. ^{{cite web | title = Entrez Gene: clusterin associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=23059| accessdate = 2011-08-30}}
2. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBDK/x-ray-imaging/ |title=Radiography data for Cluap1 |publisher=Wellcome Trust Sanger Institute}}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBDK/salmonella-challenge/ |title=Salmonella infection data for Cluap1 |publisher=Wellcome Trust Sanger Institute}}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBDK/citrobacter-challenge/ |title=Citrobacter infection data for Cluap1 |publisher=Wellcome Trust Sanger Institute}}
5. ^1 2 3 {{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages = 925–7 }}
6. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
7. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Cluap1 |title=International Knockout Mouse Consortium}}
8. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4363468 |title=Mouse Genome Informatics}}
9. ^{{Cite journal| last1 = Skarnes |first1 =W. C.| doi = 10.1038/nature10163 | last2 = Rosen | first2 = B.| last3 = West | first3 = A. P.| last4 = Koutsourakis | first4 = M.| last5 = Bushell | first5 = W.| last6 = Iyer | first6 = V.| last7 = Mujica | first7 = A. O.| last8 = Thomas | first8 = M.| last9 = Harrow | first9 = J.| last10 = Cox | first10 = T.| last11 = Jackson | first11 = D.| last12 = Severin | first12 = J.| last13 = Biggs | first13 = P.| last14 = Fu | first14 = J.| last15 = Nefedov | first15 = M.| last16 = De Jong | first16 = P. J.| last17 = Stewart | first17 = A. F.| last18 = Bradley | first18 = A. | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | year = 2011 | pmid = 21677750 | pmc =3572410 }}
10. ^{{cite journal | doi = 10.1038/474262a | title = Mouse library set to be knockout | year = 2011 | author = Dolgin E | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | pmid = 21677718 }}
11. ^{{cite journal | doi = 10.1016/j.cell.2006.12.018 | title = A Mouse for All Reasons | year = 2007 | journal = Cell | volume = 128 | pages = 9–13 | pmid = 17218247 |vauthors=Collins FS, Rossant J, Wurst W | issue = 1 }}
12. ^{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}}

External links

  • {{UCSC gene info|CLUAP1}}

Further reading

  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
  • {{cite journal |vauthors=Follit JA, Xu F, Keady BT, Pazour GJ |title=Characterization of mouse IFT complex B |journal=Cell Motility and the Cytoskeleton |volume=66 |issue= 8 |pages= 457–68 |year= 2009 |pmid= 19253336 |doi= 10.1002/cm.20346 |pmc=2753169}}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Research |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nature Genetics |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proceedings of the National Academy of Sciences USA |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
  • {{cite journal |vauthors=Ishikawa K, Nagase T, Suyama M |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Research |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi= 10.1093/dnares/5.3.169}}
  • {{cite journal |vauthors=Takahashi M, Lin YM, Nakamura Y, Furukawa Y |title=Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer |journal=Oncogene |volume=23 |issue= 57 |pages= 9289–94 |year= 2004 |pmid= 15480429 |doi= 10.1038/sj.onc.1208100 }}
  • {{cite journal |vauthors=Ishikura H, Ikeda H, Abe H |title=Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system |journal=International Journal of Oncology |volume=30 |issue= 2 |pages= 461–7 |year= 2007 |pmid= 17203229 |doi= 10.3892/ijo.30.2.461 }}
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1 : Genes mutated in mice
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