Clymer is a surname. Notable people with the surname include:

• Adam Clymer (1937-2018), American journalist
• Ben Clymer, ice hockey player
• Eleanor Clymer, children's author
• Ella Maria Dietz Clymer (1847-1920), American actress, poet
• Floyd Clymer, Pioneer motorcycle racer, dealer, publisher
• George Clymer, Signer of Declaration of Independence
• George Clymer (inventor), printer and inventor
• Hiester Clymer, Pennsylvania politician of the Hiester Family
• Jim Clymer, Pennsylvania politician
• John Clymer, American artist
• John B. Clymer, screenwriter
• Mary Willing Clymer, Philadelphia socialite
• Paul Clymer, Pennsylvania politician
• Otis Clymer, baseball player
• Wayne K. Clymer (1917–2013), American United Methodist bishop
• Reuben Swinburne Clymer (1878-1966), American occultist

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