“Codeine-N-oxide”的意思、由来-开放百科全书

词条

Codeine-N-oxide

释义

References

{{DISPLAYTITLE:Codeine-N-oxide}}{{Chembox
| Name = Codeine-N-oxide
| ImageFile = Codeine-N-oxide.svg
| ImageSize = 150px
| SystematicName = (1S,4S,5R,13R,14S,17R)-10-Methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^1,13.0^5,17.0^7,18]octadeca-7(18),8,10,15-tetraen-14-ol 4-oxide
| OtherNames =
|Section1={{Chembox Identifiers
| CASNo = 3688-65-1
| PubChem = 5359929
| ChemSpiderID = 4514400
| SMILES = [O-][N@@+]4([C@@H]3Cc5c1c(O[C@@H]2[C@]1([C@H]3/C=C\\[C@@H]2O)CC4)c(OC)cc5)C
| InChI = 1/C18H21NO4/c1-19(21)8-7-18-11-4-5-13(20)17(18)23-16-14(22-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-,19-/m0/s1
| InChIKey = BDLSDHWCOJPHIE-KFUGMXNIBR
| StdInChI = 1S/C18H21NO4/c1-19(21)8-7-18-11-4-5-13(20)17(18)23-16-14(22-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-,19-/m0/s1
| StdInChIKey = BDLSDHWCOJPHIE-KFUGMXNISA-N
|Section2={{Chembox Properties
| C=18 | H=21 | N=1 | O=4
| Appearance =
| Density =
| MeltingPt =
| BoilingPt =
| Solubility =
|Section3={{Chembox Hazards
| MainHazards =
| FlashPt =
| AutoignitionPt =
}}

Codeine-N-oxide (genocodeine) is an active metabolite of codeine.^[1] It is an opiate listed as a Schedule I controlled substance.^[2] It has a DEA ACSCN of 9053 and its annual manufacturing quota for 2013 was 602 grammes.

Like morphine-N-oxide, it was studied as a potential pharmaceutical drug and is considerably weaker than codeine. The amine oxides of this type form as oxidation products of the parent chemical; virtually every morphine/codeine class opioid has an equivalent nitrogen derivative such as hydromorphone-N-oxide.

References

1. ^{{Cite journal |author1=Phillipson, J. David |author2=El-Dabbas, Samia W. |author3=Gorrod, John W. | title = In vivo and in vitro N-oxidation of morphine and codeine | journal = Biol. Oxid. Nitrogen, Proc. Int. Symp., 2nd | year = 1978 | pages = 125–30}}
2. ^{{CodeFedReg|21|1308|11}}

2 : Amine oxides|Opiates

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。