| 词条 | Combretastatin B-1 |
| 释义 |
| Name = Combretastatin B-1 | ImageFile = Combretastatin B-1.PNG | IUPACName = 3-methoxy-6-[2-(3,4,5-trimethoxyphenyl)ethyl]benzene-1,2-diol | OtherNames = Combretastatin B1 |Section1={{Chembox Identifiers | CASNo_Ref = | CASNo = 109971-64-4 | ChEMBL_Ref = | ChEMBL = | PubChem = 135716 | SMILES = COC1=C(C(=C(C=C1)CCC2=CC(=C(C(=C2)OC)OC)OC)O)O | ChemSpiderID = 119539 | SMILES2 = O(c1cc(cc(OC)c1OC)CCc2ccc(OC)c(O)c2O)C | InChI = 1/C18H22O6/c1-21-13-8-7-12(16(19)17(13)20)6-5-11-9-14(22-2)18(24-4)15(10-11)23-3/h7-10,19-20H,5-6H2,1-4H3 | InChIKey = ZSNYQENLWQYSRK-UHFFFAOYAW | StdInChI = 1S/C18H22O6/c1-21-13-8-7-12(16(19)17(13)20)6-5-11-9-14(22-2)18(24-4)15(10-11)23-3/h7-10,19-20H,5-6H2,1-4H3 | StdInChIKey = ZSNYQENLWQYSRK-UHFFFAOYSA-N |Section2={{Chembox Properties | Formula = C18H22O6 | MolarMass = 334.36 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Combretastatin B-1 is a combretastatin and a dihydrostilbenoid. It can be found in Combretum caffrum, the Eastern Cape South African bushwillow tree[1] or in Combretum kraussii, the forest bushwillow.[2] It can be produced by selective hydrogenation of Combretastatin A-1.[1] It is a potent inhibitor of microtubule assembly in vitro.[1] References1. ^1 2 {{Cite journal | last1 = Pettit | first1 = G. R. | last2 = Singh | first2 = S. B. | last3 = Niven | first3 = M. L. | last4 = Hamel | first4 = E. | last5 = Schmidt | first5 = J. M. | title = Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum | doi = 10.1021/np50049a016 | journal = Journal of Natural Products | volume = 50 | issue = 1 | pages = 119–131 | year = 1987 | pmid = 3598594| pmc = }} {{Dihydrostilbenoid}}{{natural phenol-stub}}2. ^Uteroactive constituents from Combretum kraussii. Bridget K Brookes, Olga V Doudoukina, Lynn C Katsoulis and Joy H D Veale, South African Journal of Chemistry, Dec 99, Vol. 52, Issue 4, page 127 (abstract) 2 : Combretastatins|Dihydrostilbenoids |
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