| 词条 | Polyalkylimide |
| 释义 |
Polyalkylimide is a polymer which belongs to the family of acryl derivatives. Its polymeric structure does not contain free monomers. It is also the active ingredient in a permanent dermal filler called Bio-Alcamid (manufactured by Polymekon, Brindisi, Italy) which is a three percent polyalkylimide suspension in water used medically to treat soft tissue deficits such as facial lipoatrophy[1] and lipodystrophy, Poland syndrome, Pectus excavatum (sunken chest), gluteal atrophy, acne and scars.[2] Dr. Patrick Treacy was among the first doctors in the world to use the permanent facial endoprosthesis BioAlcamid successfully for HIV Lipodystrophy patients.[3] .[4] In plastic and reconstructive surgery it is used for building up facial volume in areas like the cheeks, chin, jaw and for lip augmentation. Since its initial use, numerous reports of adverse reactions have been reported including significant infections[5] and migration resulting in significant facial deformity.[6] Because of this, Bioalcamid has been taken off the market in Canada and the original manufacture has since stopped production. In Canada, some individuals have attempted to file class action lawsuits against the company.[7] See also
References1. ^{{Cite journal | last1 = Hönig | first1 = J. | title = Cheek Augmentation with Bio-Alcamid in Facial Lipoatrophy in HIV Seropositive Patients | doi = 10.1097/SCS.0b013e31811eda9c | journal = Journal of Craniofacial Surgery | volume = 19 | issue = 4 | pages = 1085–1088 | year = 2008 | pmid = 18650737| pmc = }} {{polymer-stub}}2. ^{{Cite journal | last1 = Pacini | first1 = S. | last2 = Ruggiero | first2 = M. | last3 = Morucci | first3 = G. | last4 = Cammarota | first4 = N. | last5 = Protopapa | first5 = C. | last6 = Gulisano | first6 = M. | title = Bio-alcamid: A novelty for reconstructive and cosmetic surgery | journal = Italian Journal of Anatomy and Embryology| volume = 107 | issue = 3 | pages = 209–214 | year = 2002 | pmid = 12437147}} 3. ^{{cite web|url = http://www.michaeljacksontributeportrait.com/article.php?article_id=274|title = Patrick Treacy, Dr.| publisher=Michael Jackson Tribute Portrait | access-date= February 28, 2016}} 4. ^{{cite journal|title = Use of a biopolymer polyalkylimide filler for facial lipodystrophy in HIV-positive patients | pmid=16792645 | doi=10.1111/j.1524-4725.2006.32164.x | volume=32 | issue=6 | year=2006 | journal=Dermatol Surg | pages=804–8 | last1 = Treacy | first1 = PJ | last2 = Goldberg | first2 = DJ}} 5. ^{{cite web|url=https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/health-product-infowatch/canadian-adverse-reaction-newsletter-volume-21-issue-1-january-2011.html|title=ARCHIVED - Canadian Adverse Reaction Newsletter, Volume 21 - Issue 1 - January 2011|first1=Health|last1=Canada|first2=Health|last2=Canada|date=16 December 2010|website=aem}} 6. ^{{cite web|url=https://www.catie.ca/en/catienews/2010-11-05/complications-reported-some-recipients-bio-alcamid|title=Complications reported in some recipients of Bio Alcamid|website=www.catie.ca}} 7. ^{{cite web|url=http://www.smithlawfirm.com/blog/2011/4/5/canadian-man-sues-maker-of-bio-alcamid-gel-claiming-disfigur.html|title=Canadian man sues maker of Bio-Alcamid gel, claiming disfigurement|website=Smith Law Firm}} 2 : Polymers|Plastic surgery filler |
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