| 词条 | Polyphagia |
| 释义 |
| name = Polyphagia | synonyms = Hyperphagia | specialty = Endocrinology, psychiatry | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Polyphagia or hyperphagia is excessive hunger or increased appetite.[1] It is a medical sign meaning excessive hunger and abnormally large intake of solids by mouth. It can be caused by disorders such as diabetes, Kleine–Levin syndrome (a malfunction in the hypothalamus),{{cn|date=February 2017}} and the genetic disorders Prader–Willi syndrome and Bardet–Biedl syndrome.[2] Knocking out vagal nerve receptors has been shown to cause hyperphagia.[3] CausesCauses of increased appetite include:[4]
Diabetic ketoacidosisPolyphagia usually occurs early in the course of diabetic ketoacidosis.[6] However, once insulin deficiency becomes more severe and ketoacidosis develops, appetite is suppressed.[7] Etymology and pronunciationThe word polyphagia ({{IPAc-en|ˌ|p|ɒ||l|i|ˈ|f|eɪ|dʒ|i|ə}}) uses combining forms of poly- + -phagia, from the Greek words πολύς (polys), "very much" or "many", and φαγῶ (phago), "eating" or "devouring". See also{{columns-list|colwidth=22em|
}} References1. ^{{cite journal| vauthors=Berthoud HR, Lenard NR, Shin AC| title=Food reward, hyperphagia, and obesity. | journal=Am J Physiol Regul Integr Comp Physiol | year= 2011 | volume= 300 | issue= 6 | pages= R1266-77 | pmid=21411768 | doi=10.1152/ajpregu.00028.2011 | pmc=3119156 }} 2. ^[https://www.ncbi.nlm.nih.gov/omim/176270 OMIM::Prader-Willi][https://www.ncbi.nlm.nih.gov/omim/209900 OMIM::Bardet-Biedl] 3. ^{{cite journal | vauthors=de Lartigue G, Ronveaux CC, Raybould HE | title=Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity | journal= MOLECULAR METABOLISM | volume=3 | issue=6 | pages=595-607 | year=2014 | url=http://www.sciencedirect.com/science/article/pii/S2212877814001148 | doi= 10.1016/j.molmet.2014.06.003 | pmc=4142400 | PMID = 25161883 }} 4. ^{{cite web|url=https://www.nlm.nih.gov/medlineplus/ency/article/003134.htm|title=Appetite - increased|author=Updated by: Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.|work=nih.gov}} 5. ^{{cite web|title=Polyphagia: Symptoms and Causes of Increased Appetite|url=http://www.diabetes.co.uk/symptoms/polyphagia.html|website=Diabetes UK|accessdate=29 December 2017}} 6. ^{{cite journal| vauthors=Elliott RE, Jane JA, Wisoff JH| title=Surgical management of craniopharyngiomas in children: meta-analysis and comparison of transcranial and transsphenoidal approaches. | journal=Neurosurgery | year= 2011 | volume= 69 | issue= 3 | pages= 630–43; discussion 643 | pmid=21499159 | doi=10.1227/NEU.0b013e31821a872d | pmc= | url= }} 7. ^{{cite journal| vauthors=Masuzaki H, Tanaka T, Ebihara K, Hosoda K, Nakao K| title=Hypothalamic melanocortin signaling and leptin resistance--perspective of therapeutic application for obesity-diabetes syndrome. | journal=Peptides | year= 2009 | volume= 30 | issue= 7 | pages= 1383–6 | pmid=19394382 | doi=10.1016/j.peptides.2009.04.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19394382 }} External links{{Medical resources| ICD10 = {{ICD10|R|63|2|r|50}} | ICD9 = {{ICD9|783.6}} | DiseasesDB=29453 | MeshID=D006963 }}
2 : Symptoms and signs: Endocrinology, nutrition, and metabolism|Polyphagia |
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