| 词条 | Cryptolepine |
| 释义 |
| ImageFile = Cryptolepine.svg | ImageSize = 200px | ImageAlt = | IUPACName = 5-Methyl-5H-indolo[3,2-b]quinoline | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 480-26-2 | PubChem = 82143 | ChemSpiderID = 74137 | ChEBI = 3930 | ChEMBL = 92129 | SMILES = N2=C1C(C=CC=C1)=C4C2=Cc3ccccc3N4C | StdInChI=1S/C16H12N2/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14/h2-10H,1H3 | StdInChIKey = KURWKDDWCJELSV-UHFFFAOYSA-N | Section2 = {{Chembox Properties | C=16 | H=12 | N=2 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Cryptolepine is an alkaloid with antimalarial and cytotoxic properties. It is able to intercalate into DNA at the cytosine-cytosine sites.[1][2] References1. ^{{Cite journal | last1 = Wright | first1 = C. W. | last2 = Addae-Kyereme | first2 = J. | last3 = Breen | first3 = A. G. | last4 = Brown | first4 = J. E. | last5 = Cox | first5 = M. F. | last6 = Croft | first6 = S. L. | last7 = Gökçek | first7 = Y. | last8 = Kendrick | first8 = H. | last9 = Phillips | first9 = R. M. | last10 = Pollet | first10 = P. L. | title = Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents | journal = Journal of Medicinal Chemistry | volume = 44 | issue = 19 | pages = 3187–3194 | year = 2001 | pmid = 11543688 | doi=10.1021/jm010929}} {{alkaloid-stub}}2. ^{{Cite journal | last1 = Onyeibor | first1 = O. | last2 = Croft | first2 = S. L. | last3 = Dodson | first3 = H. I. | last4 = Feiz-Haddad | first4 = M. | last5 = Kendrick | first5 = H. | last6 = Millington | first6 = N. J. | last7 = Parapini | first7 = S. | last8 = Phillips | first8 = R. M. | last9 = Seville | first9 = S. | last10 = Shnyder | first10 = S. D. | last11 = Taramelli | first11 = D. | last12 = Wright | first12 = C. W. | doi = 10.1021/jm040893w | title = Synthesis of Some Cryptolepine Analogues, Assessment of Their Antimalarial and Cytotoxic Activities, and Consideration of Their Antimalarial Mode of Action | journal = Journal of Medicinal Chemistry | volume = 48 | issue = 7 | pages = 2701–2709 | year = 2005 | pmid = 15801861 | pmc = }} 2 : Antimalarial agents|Experimental cancer drugs |
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