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词条 Cucurmosin
释义

  1. References

Cucurmosin is a type I ribosome inactivating protein (RIP) found in the sarcocarp (flesh) and seed of Cucurbita — notably Cucurbita moschata, that is toxic to cancer cells,[1] if the dosage is high enough, by stopping their ribosomes.[2] Cucurmosin is what Cucurbita use to defend against viral, fungal, and bacterial agents. It takes a lower dose of cucurmosin to kill cancer cells than healthy cells.[3] It has been shown to induce apoptosis in pancreatic cancer and myeloid leukemia cells.[4]

References

1. ^{{cite book|last1=Preedy|first1=Victor R.|last2=Watson|first2=Ronald Ross|last3=Patel|first3=Vinwood B.|title=Nuts and Seeds in Health and Disease Prevention|year=2011|publisher=Academic Press|location=London|page=936|isbn=978-0-12-375688-6}}
2. ^{{cite journal|last1=Barbieri |first1=L.|last2=Polito |first2=L.|last3=Bolognesi|first3=A.|last4=Ciani |first4=M.|last5=Pelosi |first5=E.|last6=Farini |first6=V.|last7=Jha|first7=A. K.|last8=Sharma|first8=N.|last9=Vivanco|first9=J. M.|last10=Chambery|first10=A.|last11=Parente |first11=A.|last12=Stirpe|first12=F.|title=Ribosome-inactivating proteins in edible plants and purification and characterization of a new ribosome-inactivating protein from Cucurbita moschata|journal= Biochimica et Biophysica Acta |volume=1760|issue=5|pages=783–792|date=May 2006|pmid=16564632 |doi=10.1016/j.bbagen.2006.01.002}}
3. ^{{cite journal|last1=Hou|first1=Xiaomin|last2=Meehan|first2=Edward J.|last3=Xie|first3=Jieming|last4=Huang|first4=Mingdong|last5=Chen|first5=Minghuang|last6=Chen|first6=Liqing|title=Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata|journal=Journal of Structural Biology|volume=164|issue=1|pages=81–87|date=October 2008|doi=10.1016/j.jsb.2008.06.011}}
4. ^{{cite journal|last1=Zhang|first1=B.|last2=Huang |first2=H.|last3=Xie|first3=J.|last4=Xu|first4=C.|last5=Chen|first5=M.|last6=Wang|first6=C.|last7=Yan|first7=A.|last8=Yin|first8=Q.|title=Cucurmosin induces apoptosis of BxPC-3 human pancreatic cancer cells via inactivation of the EGFR signaling pathway|journal=Oncology Reports|volume=27|issue=3|pages=891–897|date=March 2012|pmid=22139427|doi=10.3892/or.2011.1573}}

3 : Protein biosynthesis|Plant toxins|Ribosome-inactivating proteins

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