| 词条 | CVNH domain |
| 释义 |
| Symbol = CVNH | Name = CVNH | image = PDB 1iiy EBI.jpg | width = | caption = solution nmr structure of complex of 1:2 cyanovirin-n:man-alpha1,2-man-alpha restrained regularized mean coordinates | Pfam = PF08881 | Pfam_clan = | InterPro = IPR011058 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, the CVNH domain (CyanoVirin-N Homology domain) is a conserved protein domain. It is found in the sugar-binding antiviral protein cyanovirin-N (CVN) as well as proteins from filamentous ascomycetes and in the fern Ceratopteris richardii.[1] Cyanovirin-N (CV-N) is an 11-kDa protein from the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (AIDS). The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins gp120 and gp41, as well as to high-mannose oligosaccharides found on the HIV envelope.[2] In addition, CV-N is active against rhinoviruses, human parainfluenza virus, respiratory syncytial virus, and enteric viruses. The virucidal activity of CV-N against influenza virus is directed towards viral haemagglutinin.[3] CV-N has a complex fold composed of a duplication of a tandem repeat of two homologous motifs comprising three-stranded beta sheet and beta hairpins.[4] References1. ^{{cite journal |vauthors=Percudani R, Montanini B, Ottonello S | title = The anti-HIV cyanovirin-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes | journal = Proteins | volume = 60 | issue = 4 | pages = 670–8 |date=September 2005 | pmid = 16003744 | doi = 10.1002/prot.20543 }} {{InterPro content|IPR011058}}2. ^{{cite journal |vauthors=Wlodawer A, Botos I |title=Cyanovirin-N: a sugar-binding antiviral protein with a new twist |journal=Cell. Mol. Life Sci. |volume=60 |issue=2 |pages=277–287 |year=2003 |pmid=12678493 |doi=10.1007/s000180300023}} 3. ^{{cite journal |vauthors=Mori T, O'keefe BR, Smee DF, Turpin JA, Saucedo CJ, Gustafson KR, Blakeslee D, Buckheit R, Boyd MR |title=Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin |journal=Antimicrob. Agents Chemother. |volume=47 |issue=8 |pages=2518–2525 |year=2003 |pmid=12878514 |pmc=166092 |doi=10.1128/aac.47.8.2518-2525.2003}} 4. ^{{cite journal |vauthors=Wlodawer A, Botos I, Boyd MR, O Keefe BR, Cartner LK, Shenoy SR, Ratner DM, Seeberger PH |title=Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides |journal=J. Biol. Chem. |volume=277 |issue=37 |pages=34336–34342 |year=2002 |pmid=12110688 |doi=10.1074/jbc.M205909200}} 1 : Protein domains |
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