| 词条 | Cyclin E2 |
| 释义 |
|Name=cyclin E2 |caption= |image= |width= |HGNCid=1590 |Symbol=CCNE2 |AltSymbols= |EntrezGene=9134 |OMIM=603775 |RefSeq=NM_057749 |UniProt=O96020 |PDB= |ECnumber= |Chromosome=8 |Arm=q |Band=22.1 |LocusSupplementaryData= }}Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.[1] References1. ^1 {{cite journal | vauthors = Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S | title = Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 612–22 | date = January 1999 | pmid = 9858585 | pmc = 83919 | doi = 10.1128/mcb.19.1.612 }} {{Cell_cycle_proteins}} 1 : Proteins |
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