| 词条 | Daniel Haber |
| 释义 |
| name = Daniel A. Haber | image = | image_size = | alt = | caption = | birth_date = | birth_place = | death_date = | death_place = | resting_place = | resting_place_coordinates = | residence = | citizenship = | nationality = French | fields = Genetics | workplaces = Harvard University | alma_mater = Massachusetts Institute of Technology, Stanford University | thesis_title = | thesis_url = | thesis_year = | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = Cancer Genetics | author_abbrev_bot = | author_abbrev_zoo = | influences = | influenced = | awards = | signature = | signature_alt = | website = | footnotes = | spouse = }}Daniel A. Haber, Ph.D., M.D. is the director of Massachusetts General Hospital Cancer Center, a Professor of Oncology at Harvard Medical School, and an investigator of the Howard Hughes Medical Institute (HHMI). He earned his B.S. in life sciences and M.S. in toxicology from Massachusetts Institute of Technology, and his M.D. and Ph.D. in biophysics from Stanford University School of Medicine under the mentorship of Robert T. Schimke.[1] He did his postdoctoral training at Massachusetts Institute of Technology with David E. Housman.[2] As a postdoc, he started to study Wilms' tumor and characterized the tumor suppressor gene WT1 and WTX.[3][4] In 2003, he recognized that certain patients with lung cancer responded well to the drug Iressa where few other patients showed effect. Sequencing the patient's cancers, they identified specific mutation in epidermal growth factor receptor (EGFR) that resulted in sensitivity to certain drugs.[5][6] By linking mutations to drug sensitivity, they were able to propose new mechanisms for targeted therapies by examining the accumulation of certain mutations in cancer cells.[1] His lab is now focused on studying the genetics of cancer particularly in circulating tumor cells with Mehmet Toner. He is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Medicine, the National Academy of Sciences, the Association of American Physicians, and the American Society for Clinical Investigation. He is an editor of Cell and Cancer Cell.[2] External links
References1. ^1 {{cite web|title=Daniel A. Haber|url=http://www.hhmi.org/research/investigators/haber_bio.html|publisher=HHMI|accessdate=10 November 2012}} {{authority control}}{{DEFAULTSORT:Haber, Daniel}}{{US-biochemist-stub}}2. ^1 {{cite web|title=Daniel Haber, M.D., Ph.D.|url=http://www.standup2cancer.org/dream_team_leaders/view/daniel_haber_m.d._ph.d|accessdate=10 November 2012}} 3. ^{{cite journal|last=Haber|first=DA|author2=Buckler, AJ |author3=Glaser, T |author4=Call, KM |author5=Pelletier, J |author6=Sohn, RL |author7=Douglass, EC |author8= Housman, DE |title=An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.|journal=Cell|date=Jun 29, 1990|volume=61|issue=7|pages=1257–69|pmid=2163761|doi=10.1016/0092-8674(90)90690-g}} 4. ^{{cite web|title=MERIT Award Recipient: Daniel A. Haber, M.D., Ph.D.|url=http://www.cancer.gov/researchandfunding/MERIT/haber|accessdate=10 November 2012}} 5. ^{{cite journal|last=Lynch|first=Thomas J.|author2=Bell, Daphne W. |author3=Sordella, Raffaella |author4=Gurubhagavatula, Sarada |author5=Okimoto, Ross A. |author6=Brannigan, Brian W. |author7=Harris, Patricia L. |author8=Haserlat, Sara M. |author9=Supko, Jeffrey G. |author10=Haluska, Frank G. |author11=Louis, David N. |author12=Christiani, David C. |author13=Settleman, Jeff |author14=Haber, Daniel A. |title=Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib|journal=New England Journal of Medicine|date=20 May 2004|volume=350|issue=21|pages=2129–2139|doi=10.1056/NEJMoa040938|pmid=15118073}} 6. ^{{cite journal|last=Sordella|first=R|author2=Bell, DW |author3=Haber, DA |author4= Settleman, J |title=Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways.|journal=Science|date=Aug 20, 2004|volume=305|issue=5687|pages=1163–7|pmid=15284455|doi=10.1126/science.1101637}} 9 : Living people|American biochemists|Howard Hughes Medical Investigators|Harvard Medical School faculty|Massachusetts Institute of Technology alumni|Stanford Medical School alumni|Fellows of the American Academy of Arts and Sciences|Members of the National Academy of Medicine|Year of birth missing (living people) |
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