| 词条 | Delanterone |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (1S,8S,9S,10R,13R,14S)-1,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one | image = Delanterone.svg | width = 225px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 63014-96-0 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | PubChem = 205969 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 178468 | UNII = AM2KZ47R0J | ChEMBL = 2104221 | synonyms = GBR-21162; 1α-Methylandrosta-4,16-dien-3-one | C=20 | H=28 | O=1 | molecular_weight = 284.43572 g/mol | SMILES = CC1CC(=O)C=C2C1(C3CCC4(C=CCC4C3CC2)C)C | StdInChI_Ref = | StdInChI = 1S/C20H28O/c1-13-11-15(21)12-14-6-7-16-17-5-4-9-19(17,2)10-8-18(16)20(13,14)3/h4,9,12-13,16-18H,5-8,10-11H2,1-3H3/t13-,16-,17-,18-,19-,20-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = GDONNNQFENTLQC-VWTPSIDOSA-N }}Delanterone ({{abbrlink|INN|International Nonproprietary Name}}) (developmental code name GBR-21162), also known as 1α-methylandrosta-4,16-dien-3-one, is a steroidal antiandrogen described as an anti-acne agent which was never marketed.[1][2][3] The compound showed poor efficacy as an antiandrogen in vivo in animals, suggestive of low activity or a short terminal half-life, and likely in relation to this was not further developed.[3] It was described and characterized in the literature in 1977.[1][3] See also
References1. ^1 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA794|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=794–}} {{Androgen receptor modulators}}{{steroid-stub}}{{dermatologic-drug-stub}}2. ^{{cite book|author1=Martin Negwer|author2=Hans-Georg Scharnow|title=Organic-chemical drugs and their synonyms: (an international survey)|url=https://books.google.com/books?id=zmpqAAAAMAAJ|year=2001|publisher=Wiley-VCH|isbn=978-3-527-30247-5}} 3. ^1 2 {{cite journal|last1=Singh|first1=Shankar|last2=Gauthier|first2=Sylvain|last3=Labrie|first3=Fernand|title=Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships|journal=Current Medicinal Chemistry|volume=7|issue=2|year=2000|pages=211–247|issn=0929-8673|doi=10.2174/0929867003375371|pmid=10637363}} 4 : Androstanes|Anti-acne preparations|Cyclopentenes|Steroidal antiandrogens |
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