Descombes is a French language surname that may refer to:

• Colette Descombes, French film actress
• Émile Descombes (1829–1912), French pianist
• Jeanie Descombes (born 1935), American baseball player
• Vincent Descombes (born 1943), French philosopher
• Vincent Descombes Sevoie (born 1984), French ski jumper

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