“Diadenosine hexaphosphate hydrolase (AMP-forming)”的意思、由来-开放百科全书

词条

Diadenosine hexaphosphate hydrolase (AMP-forming)

释义

References
External links

{{Infobox enzyme
| Name = Diadenosine hexaphosphate hydrolase (AMP-forming)
| EC_number = 3.6.1.60
| CAS_number =
| IUBMB_EC_number = 3/6/1/60
| GO_code =
| image =
| width =
| caption =
}}Diadenosine hexaphosphate hydrolase (AMP-forming) ({{EC number|3.6.1.60}}, hAps1, NUDT11 (gene), hAps2, NUDT10 (gene)) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming).^[1]^[2] This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H₂O adenosine 5'-pentaphosphate + AMP

(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H₂O adenosine 5'-tetraphosphate + AMP

A divalent cation is essential for activity.

References

1. ^{{cite journal | vauthors = Leslie NR, McLennan AG, Safrany ST | title = Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases | journal = BMC Biochemistry | volume = 3 | pages = 20 | date = July 2002 | pmid = 12121577 | pmc = 117780 | doi = 10.1186/1471-2091-3-20 }}
2. ^{{cite journal | vauthors = Safrany ST, Ingram SW, Cartwright JL, Falck JR, McLennan AG, Barnes LD, Shears SB | title = The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein | journal = The Journal of Biological Chemistry | volume = 274 | issue = 31 | pages = 21735–40 | date = July 1999 | pmid = 10419486 | doi = 10.1074/jbc.274.31.21735 }}

External links

{{MeshName|Diadenosine+hexaphosphate+hydrolase+(AMP-forming)}}

1 : EC 3.6.1

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