| 词条 | Di-haem cytochrome c peroxidase |
| 释义 |
| Symbol = CCP_MauG | Name = Di-haem cytochrome c peroxidase | image = PDB 1eb7 EBI.jpg | width = | caption = crystal structure of the di-haem cytochrome c peroxidase from pseudomonas aeruginosa | Pfam = PF03150 | Pfam_clan = CL0318 | InterPro = IPR004852 | SMART = | PROSITE = | MEROPS = | SCOP = 1eb7 | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, the di-haem cytochrome c peroxidase family is a group of distinct cytochrome c peroxidases (CCPs) that contain two haem groups. Similar to other cytochrome c peroxidases, they reduce hydrogen peroxide to water using c-type haem as an oxidizable substrate. However, since they possess two, instead of one, haem prosthetic groups, this family of bacterial CCPs reduce hydrogen peroxide without the need to generate semi-stable free radicals. The two haem groups have significantly different redox potentials. The high potential (+320 mV) haem feeds electrons from electron shuttle proteins to the low potential (-330 mV) haem, where peroxide is reduced (indeed, the low potential site is known as the peroxidatic site).[1] The CCP protein itself is structured into two domains, each containing one c-type haem group, with a calcium-binding site at the domain interface. This family also includes MauG proteins, whose similarity to di-haem CCP was previously recognised.[2] References1. ^{{cite journal |vauthors=Fulop V, Ridout CJ, Greenwood C, Hajdu J | title = Crystal structure of the di-haem cytochrome c peroxidase from Pseudomonas aeruginosa | journal = Structure | volume = 3 | issue = 11 | pages = 1225–33 |date=November 1995 | pmid = 8591033 | doi = 10.1016/s0969-2126(01)00258-1| url = }} {{InterPro content|IPR004852}}2. ^{{cite journal |vauthors=Gak ER, Tsygankov YD, Chistoserdov AY | title = Organization of methylamine utilization genes (mau) in 'Methylobacillus flagellatum ' KT and analysis of mau mutants | journal = Microbiology | volume = 143 | issue = 6| pages = 1827–35 |date=June 1997 | pmid = 9202457 | doi = 10.1099/00221287-143-6-1827| url = }} 1 : Protein families |
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