请输入您要查询的百科知识:

 

词条 Dihydroorotate dehydrogenase (fumarate)
释义

  1. References

  2. External links

{{Infobox enzyme
| Name = Dihydroorotate dehydrogenase (fumarate)
| EC_number = 1.3.98.1
| CAS_number = 2603876
| IUBMB_EC_number = 1/3/98/1
| GO_code =
| image =
| width =
| caption =
}}Dihydroorotate dehydrogenase (fumarate) ({{EC number|1.3.98.1}}, dihydroorotate oxidase, pyr4 (gene)) is an enzyme with systematic name (S)-dihydroorotate:fumarate oxidoreductase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

(S)-dihydroorotate + fumarate orotate + succinate

This enzyme contains FMN.

References

1. ^{{cite journal | title = Active site of dihydroorotate dehydrogenase A from Lactococcus lactis' investigated by chemical modification and mutagenesis |author1 = Björnberg, O. |author2 =Rowland, P. |author3 =Larsen, S. |author4 =Jensen, K.F. |journal = Biochemistry |year = 1997 |volume = 36 |pages = 16197–16205 |pmid = 9405053 |doi=10.1021/bi971628y |issue=51}}
2. ^{{cite journal | title = The crystal structure of Lactococcus lactis
' dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function |author1 = Rowland, P. |author2 =Björnberg, O. |author3 =Nielsen, F.S. |author4 =Jensen, K.F. |author5 =Larsen, S. |journal = Protein Sci. |year = 1998 |volume = 7 |pages = 1269–1279 |pmid = 9655329 |doi=10.1002/pro.5560070601 |pmc=2144028}}
3. ^{{cite journal | title = Lactococcus lactis'' dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function |author1 = Nørager, S. |author2 =Arent, S. |author3 =Björnberg, O. |author4 =Ottosen, M. |author5 =Lo Leggio, L. |author6 =Jensen, K.F. |author7 =Larsen, S. | journal = J. Biol. Chem. |year = 2003 |volume = 278 |pages = 28812–28822 |pmid = 12732650 |doi=10.1074/jbc.M303767200 |issue=31}}
4. ^{{cite journal | title = Dihydroorotate dehydrogenase from
Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues |author1 = Zameitat, E. |author2 =Pierik, A.J. |author3 =Zocher, K. |author4 =Löffle, M. |journal = FEMS Yeast Res. |year = 2007 |volume = 7 |pages = 897–904 |pmid = 17617217 |doi=10.1111/j.1567-1364.2007.00275.x |issue=6}}
5. ^{{cite journal | title = Structures of
Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction |author1 = Inaoka, D.K. |author2 =Sakamoto, K. |author3 =Shimizu, H. |author4 =Shiba, T. |author5 =Kurisu, G. |author6 =Nara, T. |author7 =Aoki, T. |author8 =Kita, K. |author9 =Harada, S. | journal = Biochemistry |year = 2008 |volume = 47 |pages = 10881–10891 |pmid = 18808149 |doi=10.1021/bi800413r |issue=41}}
6. ^{{cite journal | title = Kinetic mechanism and catalysis of
Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry |author1 = Cheleski, J. |author2 =Wiggers, H.J. |author3 =Citadini, A.P. |author4 =da Costa Filho, A.J. |author5 =Nonato, M.C. |author6 =Montanari, C.A. | journal = Anal. Biochem. |year = 2010 |volume = 399 |pages = 13–22 |pmid = 19932077 |doi=10.1016/j.ab.2009.11.018 |issue=1}}

External links

  • {{MeshName|Dihydroorotate+dehydrogenase+(fumarate)}}
{{CH-CH oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{Enzyme-stub}}

1 : EC 1.3.98

随便看

 

开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。

 

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间:2024/9/21 16:30:38