| 词条 | Dihydrotetrabenazine |
| 释义 |
| Name = Dihydrotetrabenazine | ImageFile=DTBZ ambiguous.svg | ImageSize=250px |Section1={{Chembox Identifiers | CASNo=3466-75-9 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 110379 | PubChem = 123836 | SMILES = COC1=C(OC)C=C(C(CC(O)C(CC(C)C)C2)N2CC3)C3=C1 | InChI = InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3 | InChIKey = WEQLWGNDNRARGE-UHFFFAOYSA-N |Section2={{Chembox Properties | C=19 | H=29 | N=1 | O=3 }}Dihydrotetrabenazine or DTBZ is an organic compound with the chemical formula C19H29NO3. It is a close analog of tetrabenazine. DTBZ and its derivatives, when labeled with positron emitting isotopes such as carbon-11 and fluorine-18, are used as PET radioligands for examining VMAT2.[1] Use in Positron Emission TomographyVMAT2 is a membrane bound protein and a biomarker for Parkinson's disease. Binding of DTBZ to VMAT2 in individuals with Parkinson's disease is significantly reduced.[5] Moreover, the VMAT2 density as determined by [18F]DTBZ has been shown to be well, inversely correlated with the severity of Parkinson's disease.[6] Avid Radiopharmaceuticals has sponsored clinical trials of [18F]AV-133 (or [18F]Fluoropropyl-(+)-DTBZ) to identify subjects with dopaminergic degeneration.[7]See also
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