“DNA-SCARS”的意思、由来-开放百科全书

词条

DNA-SCARS

释义

History
References

DNA-SCARS (short for DNA segments with chromatin alterations reinforcing senescence) are nuclear substructures with persistent DNA damage and DNA damage response proteins found in senescent cells. DNA-SCARS are associated with PML nuclear bodies and the accumulation of activated ATM, ATR, CHK2 and p53 proteins. DNA-SCARS lack most of the characteristics of transient, reversible DNA damage foci, such as single-stranded DNA, active DNA synthesis, and DNA repair proteins RPA and RAD51.^[1] Telomere dysfunction-induced foci (TIF) are generally associated with DNA-SCARS.^[1]

Together with senescence-associated heterochromatin foci (SAHF), DNA-SCARS are one of the most prevalent nuclear markers of cellular senescence.^[2]

History

DNA-SCARS were discovered by Judith Campisi and colleagues, who first described them in 2011, although most of their characteristics were previously known.^[1]

References

1. ^¹²{{cite journal|last1=Rodier|first1=F|last2=Muñoz|first2=DP|last3=Teachenor|first3=R|last4=Chu|first4=V|last5=Le|first5=O|last6=Bhaumik|first6=D|last7=Coppé|first7=JP|last8=Campeau|first8=E|last9=Beauséjour|first9=CM|last10=Kim|first10=SH|last11=Davalos|first11=AR|last12=Campisi|first12=J|title=DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion.|journal=Journal of Cell Science|date=1 January 2011|volume=124|issue=Pt 1|pages=68–81|pmid=21118958|doi=10.1242/jcs.071340|pmc=3001408}}
2. ^{{cite journal|last1=Rodier|first1=F.|last2=Campisi|first2=J.|title=Four faces of cellular senescence|journal=The Journal of Cell Biology|date=14 February 2011|volume=192|issue=4|pages=547–556|doi=10.1083/jcb.201009094|pmc=3044123}}

3 : Cellular senescence|Cell nucleus|DNA

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