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| Name = Dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
| EC_number = 2.4.1.259
| CAS_number =
| IUBMB_EC_number = 2/4/1/259
| GO_code =
| image =
| width =
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}}Dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase ({{EC number|2.4.1.259}}, ALG9, ALG9 alpha1,2 mannosyltransferase, dolichylphosphomannose-dependent ALG9 mannosyltransferase, ALG9 mannosyltransferase, Dol-P-Man:Man6GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase) is an enzyme with systematic name dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolicholD-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate
References
1. ^{{cite journal | vauthors = Vleugels W, Keldermans L, Jaeken J, Butters TD, Michalski JC, Matthijs G, Foulquier F | title = Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient | journal = Glycobiology | volume = 19 | issue = 8 | pages = 910–7 | date = August 2009 | pmid = 19451548 | doi = 10.1093/glycob/cwp067 }}
2. ^{{cite journal | vauthors = Cipollo JF, Trimble RB | title = The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing | journal = The Journal of Biological Chemistry | volume = 275 | issue = 6 | pages = 4267–77 | date = February 2000 | pmid = 10660594 | doi = 10.1074/jbc.275.6.4267 }}
3. ^{{cite journal | vauthors = Frank CG, Aebi M | title = ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis | journal = Glycobiology | volume = 15 | issue = 11 | pages = 1156–63 | date = November 2005 | pmid = 15987956 | doi = 10.1093/glycob/cwj002 }}
2. ^{{cite journal | vauthors = Cipollo JF, Trimble RB | title = The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing | journal = The Journal of Biological Chemistry | volume = 275 | issue = 6 | pages = 4267–77 | date = February 2000 | pmid = 10660594 | doi = 10.1074/jbc.275.6.4267 }}
3. ^{{cite journal | vauthors = Frank CG, Aebi M | title = ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis | journal = Glycobiology | volume = 15 | issue = 11 | pages = 1156–63 | date = November 2005 | pmid = 15987956 | doi = 10.1093/glycob/cwj002 }}
External links
- {{MeshName|Dolichyl-P-Man:Man6GlcNAc2-PP-dolichol+alpha-1,2-mannosyltransferase}}
1 : EC 2.4.1