“Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase”的意思、由来-开放百科全书

词条

Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

释义

References
External links

{{Infobox enzyme
| Name = Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
| EC_number = 2.4.1.261
| CAS_number =
| IUBMB_EC_number = 2/4/1/261
| GO_code =
| image =
| width =
| caption =
}}Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase ({{EC number|2.4.1.261}}, ALG9, ALG9 alpha1,2 mannosyltransferase, dolichylphosphomannose-dependent ALG9 mannosyltransferase, ALG9 mannosyltransferase, Dol-P-Man:Man8GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase) is an enzyme with systematic name dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase.^[1]^[2] This enzyme catalyses the following chemical reaction

dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate

The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate.

References

1. ^{{cite journal | vauthors = Vleugels W, Keldermans L, Jaeken J, Butters TD, Michalski JC, Matthijs G, Foulquier F | title = Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient | journal = Glycobiology | volume = 19 | issue = 8 | pages = 910–7 | date = August 2009 | pmid = 19451548 | doi = 10.1093/glycob/cwp067 }}
2. ^{{cite journal | vauthors = Frank CG, Aebi M | title = ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis | journal = Glycobiology | volume = 15 | issue = 11 | pages = 1156–63 | date = November 2005 | pmid = 15987956 | doi = 10.1093/glycob/cwj002 }}

External links

{{MeshName|Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol+alpha-1,2-mannosyltransferase}}

1 : EC 2.4.1

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。