Donald Bryant may refer to:

• Donald "Isa" Hamm Bryant (1943–2007), American author, historian and activist
• Don Bryant (songwriter) (born 1942), American singer and songwriter
• Don Bryant (baseball) (1941–2015), catcher and coach in Major League Baseball
• Donald A. Bryant, American bioscientist and author
• Donald L. Bryant Jr. (born 1942), American businessman, art collector, vineyard owner and philanthropist

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