| 词条 | Dopastin |
| 释义 |
| ImageFile = Dopastin.svg | ImageSize = | SystematicName = (2E)-N(2S)-2-[Hydroxy(nitroso)amino]-3-methylbutyl2-butenamide | OtherNames = |Section1={{Chembox Identifiers | CASNo = 37134-80-8 | PubChem = 6434226 | ChemSpiderID = 4939169 | SMILES = O=C(NC[C@@H](N(O)N=O)C(C)C)/C=C/C | InChI = 1/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1 | InChIKey = FJUBKTNNXRFHFD-WTSVBCDHBR | StdInChI = 1S/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1 | StdInChIKey = FJUBKTNNXRFHFD-WTSVBCDHSA-N |Section2={{Chembox Properties | C=9 | H=17 | N=3 | O=3 | Appearance = | Density = | MeltingPtC = 116 to 119 | MeltingPt_ref = [1] | BoilingPt = | Solubility = | pKa = 5.1[1] |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Dopastin is a chemical compound produced by the bacteria Pseudomonas No. BAC-125.[2] It was first isolated and characterized in 1972. It is an inhibitor of the enzyme dopamine β-hydroxylase.[3] Dopastin can be prepared synthetically from L-valinol.[4] References1. ^1 Merck Index, 11th Edition, 3417 {{Monoamine metabolism modulators}}2. ^{{cite journal | pmid = 4648494 | year = 1972 | last1 = Iimura | first1 = H | last2 = Takeuchi | first2 = T | last3 = Kondo | first3 = S | last4 = Matsuzaki | first4 = M | last5 = Umezawa | first5 = H | title = Dopastin, an inhibitor of dopamine -hydroxylase | volume = 25 | issue = 8 | pages = 497–500 | journal = The Journal of Antibiotics | doi=10.7164/antibiotics.25.497}} 3. ^{{cite journal | title = Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase |author1=H. Iinuma |author2=M. Matsuzaki |author3=T. Nagatsu |author4=T. Takeuchi |author5=H. Umezawa | journal = Agric. Biol. Chem. | year = 1974 | volume = 38 | pages = 2107–2111 | doi = 10.1271/bbb1961.38.2107 | issue = 11}} 4. ^{{cite journal | doi = 10.1039/C39730000147 | title = Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin | year = 1973 | last1 = Ohno | first1 = M. | last2 = Iinuma | first2 = H. | last3 = Yagisawa | first3 = N. | last4 = Shibahara | first4 = S. | last5 = Suhara | first5 = Y. | last6 = Kondo | first6 = S. | last7 = Maeda | first7 = K. | last8 = Umezawa | first8 = H. | journal = Journal of the Chemical Society, Chemical Communications | issue = 4 | pages = 147 }} 2 : Nitrosamines|Dopamine beta hydroxylase inhibitors |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。