| 词条 | DR-4485 |
| 释义 |
| IUPAC_name = 6-chloro-2a-(4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl)-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)one | image = DR-4485_structure.png | width = 200 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 402942-53-4 | PubChem = 9911844 | ChemSpiderID = 8087495 | C=26 | H=28 | Cl=2 | N=2 | O=1 | molecular_weight = 455.418 g/mol | smiles = c4cc(Cl)ccc4C(CC5)=CCN5CCCCC2(CCC3)c1c3c(Cl)ccc1NC2=O | StdInChI = 1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31) | StdInChIKey = SBTRHJHOLCAPFT-UHFFFAOYSA-N }}DR-4485 is a compound which acts as a potent and selective antagonist for the 5-HT7 receptor, with good oral bioavailability. It has been used to research the function of this still comparatively little studied serotonin receptor subtype.[1][2] References1. ^Kikuchi C, Suzuki H, Hiranuma T, Koyama M. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorganic & Medicinal Chemistry Letters. 2003 Jan 6;13(1):61-4. {{PMID|12467617}} {{Serotonergics}}{{nervous-system-drug-stub}}2. ^Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2384-92. DOI 10.1021/jm8014553. {{PMID|19326916}} 2 : Serotonin antagonists|5-HT7 antagonists |
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