PSAC is an acronym that can represent:

• Pennsylvania State Athletic Conference, a college sports conference in the United States
• President's Science Advisory Committee, an advising body to the U.S. President from Truman to Nixon
• Public Service Alliance of Canada, a Canadian labour union
• Pugets Sound Agricultural Company, a subsidiary of the Hudson's Bay Company

• The lodge recording studio
• The Lodge Recording Studio
• The Lodger (novel)
• The Lodge RSPB reserve
• The Lodge School
• Thelodonts
• The Loe
• The Loft Literary Center
• The Loft (XM)
• The Lofty and the Lowly
• The Lofty and the Lowly, or Good in All and None All Good
• The Lofty Pillars
• The Logan Family
• The Logdriver's Waltz
• The logical Journey of the Zoombinis
• The Logical Language Group
• The Logical Song (Scooter)
• The Logical Song (Scooter song)
• The Logical Song (song)
• The Logical Song (Supertramp)
• The Logician Devil
• The Logic of Chance
• The Logic Of Chance
• The Logic of Life
• The Logic of Life: The Rational Economics of an Irrational World