| 词条 | Pulmonary heart disease |
| 释义 |
| name = Pulmonary heart disease | synonyms = | image = Heart - cor pulmonale- right ventricular hypertrophy (4351912426).jpg | caption = Right ventricular hypertrophy | pronounce = | field = Pulmonology | symptoms = | complications = | onset = | duration = | types = | causes = Primary pulmonary hypertension[1] | risks = | diagnosis = EKG, Thrombophilia screen [2] | differential = | prevention = | treatment = Vasodilators, Diuretics[3] | medication = | prognosis = | frequency = | deaths = }}Pulmonary heart disease, also known as cor pulmonale, is the enlargement and failure of the right ventricle of the heart as a response to increased vascular resistance (such as from pulmonic stenosis) or high blood pressure in the lungs.[1] Chronic pulmonary heart disease usually results in right ventricular hypertrophy (RVH),[2] whereas acute pulmonary heart disease usually results in dilatation.[3] Hypertrophy is an adaptive response to a long-term increase in pressure. Individual muscle cells grow larger (in thickness) and change to drive the increased contractile force required to move the blood against greater resistance. Dilatation is a stretching (in length) of the ventricle in response to acute increased pressure.[4] To be classified as pulmonary heart disease, the cause must originate in the pulmonary circulation system; RVH due to a systemic defect is not classified as pulmonary heart disease. Two causes are vascular changes as a result of tissue damage (e.g. disease, hypoxic injury), and chronic hypoxic pulmonary vasoconstriction. If left untreated, then death may result. The heart and lungs are intricately related; whenever the heart is affected by a disease, the lungs risk following and vice versa. {{citation needed|date=May 2017}} Signs and symptoms{{listen| filename = Wheeze2O noise reduced.ogg | title = Wheezing | description = The sound of wheezing as heard with a stethoscope. | format = Ogg }} The symptoms/signs of pulmonary heart disease (cor pulmonale) can be non-specific and depend on the stage of the disorder, and can include blood backing up into the systemic venous system, including the hepatic vein.[5][6] As pulmonary heart disease progresses, most individuals will develop symptoms like:[7] {{columns-list|colwidth=30em|
}} CausesThe causes of pulmonary heart disease (cor pulmonale) are the following: {{columns-list|colwidth=30em|
}} PathophysiologyThe pathophysiology of pulmonary heart disease (cor pulmonale) has always indicated that an increase in right ventricular afterload causes RV failure (pulmonary vasoconstriction, anatomic disruption/pulmonary vascular bed and increased blood viscosity are usually involved [7]), however most of the time, the right ventricle adjusts to an overload in chronic pressure. According to Voelkel, et al., pressure overload is the initial step for changes in RV, other factors include:[13] {{columns-list|colwidth=30em|
}} DiagnosisInvestigations available to determine the cause of cor pulmonale include the following:[7]
Differential diagnosisThe diagnosis of pulmonary heart disease is not easy as both lung and heart disease can produce similar symptoms. Therefore, the differential diagnosis should assess:[26] {{columns-list|colwidth=30em|
}} TreatmentThe treatment for cor pulmonale can include the following: antibiotics, expectorants, oxygen therapy, diuretics, digitalis, vasodilators, and anticoagulants. Some studies have indicated that Shenmai injection with conventional treatment is safe and effective for cor pulmonale (chronic).[14] Treatment requires diuretics (to decrease strain on the heart).[7] Oxygen is often required to resolve the shortness of breath. Additionally, oxygen to the lungs also helps relax the blood vessels and eases right heart failure.[15] When wheezing is present, the majority of individuals require a bronchodilator.[7] A variety of medications have been developed to relax the blood vessels in the lung, calcium channel blockers are used[16] but only work in few cases and according to NICE are not recommended for use at all.[17] Anticoagulants are used when venous thromboembolism is present. Venesection is used in severe secondary polycythemia (because of hypoxia), which improves symptoms though survival rate has not been proven to increase.Finally, transplantation of single/double lung in extreme cases of cor pulmonale is also an option.[7] EpidemiologyThe epidemiology of pulmonary heart disease (cor pulmonale) accounts for 7% of all heart disease in the U.S.[18] According to Weitzenblum, et al., the mortality that is related to cor pulmonale is not easy to ascertain, as it is a complication of COPD.[19] See also
References1. ^1 2 3 4 5 6 7 8 {{Cite web|title = Cor pulmonale: MedlinePlus Medical Encyclopedia|url = https://www.nlm.nih.gov/medlineplus/ency/article/000129.htm|website = www.nlm.nih.gov|accessdate = 2015-12-21}} 2. ^{{Cite journal|title = Right Ventricular Function and Failure Report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure|url = http://circ.ahajournals.org/content/114/17/1883|journal = Circulation|date = 2006-10-24|issn = 0009-7322|pmid = 17060398|pages = 1883–1891|volume = 114|issue = 17|doi = 10.1161/CIRCULATIONAHA.106.632208|first = Norbert F.|last = Voelkel|first2 = Robert A.|last2 = Quaife|first3 = Leslie A.|last3 = Leinwand|first4 = Robyn J.|last4 = Barst|first5 = Michael D.|last5 = McGoon|first6 = Daniel R.|last6 = Meldrum|first7 = Jocelyn|last7 = Dupuis|first8 = Carlin S.|last8 = Long|first9 = Lewis J.|last9 = Rubin}} 3. ^{{Cite journal|title = Acute Right Ventricular Failure in the Setting of Acute Pulmonary Embolism or Chronic Pulmonary Hypertension: A Detailed Review of the Pathophysiology, Diagnosis, and Management|journal = Current Cardiology Reviews|date = 2008-02-01|issn = 1573-403X|pmc = 2774585|pmid = 19924277|pages = 49–59|volume = 4|issue = 1|doi = 10.2174/157340308783565384|first = Jennifer Cowger|last = Matthews|first2 = Vallerie|last2 = McLaughlin}} 4. ^{{Cite web|title = Types of Cardiomyopathy - NHLBI, NIH|url = http://www.nhlbi.nih.gov/health/health-topics/topics/cm/types|website = www.nhlbi.nih.gov|accessdate = 2015-12-22}} 5. ^{{Cite book|title = Chest Medicine: Essentials of Pulmonary and Critical Care Medicine|url = https://books.google.com/books?id=ZzlX2zJMbdgC|publisher = Lippincott Williams & Wilkins|date = 2005-01-01|page=226|isbn = 9780781752732|first = Ronald B.|last = George}} 6. ^http://www.medscape.com/viewarticle/458659_6 7. ^1 2 3 4 5 6 {{Cite web|title = Cor Pulmonale. Pulmonary heart disease information. Patient {{!}} Patient|url = http://patient.info/doctor/cor-pulmonale|website = Patient|accessdate = 2015-12-22|language = en-GB}} 8. ^{{Cite web|title = Blood clots: MedlinePlus Medical Encyclopedia|url = https://www.nlm.nih.gov/medlineplus/ency/article/001124.htm|website = www.nlm.nih.gov|accessdate = 2015-12-22}} 9. ^{{Cite book|title = The AHA Clinical Cardiac Consult|url = https://books.google.com/books?id=bni5B2YZFGIC|publisher = Lippincott Williams & Wilkins|date = 2010-10-18|page=136|isbn = 9781608316229|first = J. V.|last = Nixon}} 10. ^{{Cite book|title = Professional Guide to Diseases|url = https://books.google.com/books?id=1h6vu60L6FcC|publisher = Lippincott Williams & Wilkins|date = 2009-01-01|page=139|isbn = 9780781778992|first = Lippincott Williams &|last = Wilkins}} 11. ^{{Cite book|title = New Developments in Sickle Cell Disease Research|url = https://books.google.com/books?id=qzxcbWm3fe8C|publisher = Nova Publishers|date = 2006-01-01|page=214|isbn = 9781594547928|first = Paul D.|last = O'Malley}} 12. ^{{Cite book|title = Avery's Neonatology: Pathophysiology & Management of the Newborn|url = https://books.google.com/books?id=DqyS6enAS4sC|publisher = Lippincott Williams & Wilkins|date = 2005-01-01|page=699|isbn = 9780781746434|first = Mhairi G.|last = MacDonald|first2 = Mary M. K.|last2 = Seshia|first3 = Martha D.|last3 = Mullett}} 13. ^{{Cite journal|title = Mechanisms of right heart failure—A work in progress and a plea for failure prevention|journal = Pulmonary Circulation|date = 2013-01-01|issn = 2045-8932|pmc = 3641721|pmid = 23662190|pages = 137–143|volume = 3|issue = 1|doi = 10.4103/2045-8932.109957|first = Norbert F.|last = Voelkel|first2 = Jose|last2 = Gomez-Arroyo|first3 = Antonio|last3 = Abbate|first4 = Harm J.|last4 = Bogaard}} 14. ^1 {{Cite journal|title = Shenmai injection as an adjuvant treatment for chronic cor pulmonale heart failure: a systematic review and meta-analysis of randomized controlled trials|journal = BMC Complementary and Alternative Medicine|date = 2015-11-24|issn = 1472-6882|pmc = 4659214|pmid = 26603978|volume = 15|pages = 418|doi = 10.1186/s12906-015-0939-2|first = Liwei|last = Shi|first2 = Yanming|last2 = Xie|first3 = Xing|last3 = Liao|first4 = Yan|last4 = Chai|first5 = Yanhua|last5 = Luo}} 15. ^{{Cite book|title = Chest Medicine: Essentials of Pulmonary and Critical Care Medicine|url = https://books.google.com/books?id=ZzlX2zJMbdgC|publisher = Lippincott Williams & Wilkins|date = 2005-01-01|page=227|isbn = 9780781752732|first = Ronald B.|last = George}} 16. ^{{Cite web|title = Calcium Channel Blockers|url = http://livertox.nih.gov/CalciumChannelBlockers.htm|website = livertox.nih.gov|accessdate = 2015-12-22}} 17. ^{{Cite web|title = Calcium channel blockers are not recommended for the treatment of cor pulmonale. {{!}} NICE|url = http://www.nice.org.uk/donotdo/calcium-channel-blockers-are-not-recommended-for-the-treatment-of-cor-pulmonale|website = www.nice.org.uk|accessdate = 2015-12-22}} 18. ^1 {{Cite journal|title = Cor Pulmonale: Introduction to Cor Pulmonale, Etiology and Pathophysiology of Cor Pulmonale, Epidemiology of Cor Pulmonale|url = http://emedicine.medscape.com/article/154062-overview#a3|date = 2018-11-16}} 19. ^{{Cite journal|title = CHRONIC COR PULMONALE|journal = Heart|date = 2003-02-01|issn = 1355-6037|pmc = 1767533|pmid = 12527688|pages = 225–230|volume = 89|issue = 2|first = Emmanuel|last = Weitzenblum|doi=10.1136/heart.89.2.225}} Further reading
External links{{Medical resources| DiseasesDB = | ICD10 = {{ICD10|I|26||i|26}}, {{ICD10|I|27||i|26}} | ICD9 = {{ICD9|415.0}} | ICDO = | OMIM = | MedlinePlus = 000129 | eMedicineSubj = | eMedicineTopic = | MeshID = D011660 }}{{Circulatory system pathology}}{{Medicine}}{{Authority control}} 2 : Pulmonary heart disease and diseases of pulmonary circulation|Cardiomegaly |
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