| 词条 | Elamipretide |
| 释义 |
| drug_name = | INN = | type = | IUPAC_name = (2S)-6-Amino-2-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide | image = Elamipretide structure.svg | alt = | caption = | pronounce = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | routes_of_administration = | legal_AU = | legal_AU_comment = | legal_BR = | legal_BR_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion = | CAS_number = 736992-21-5 | class = | ATCvet = | ATC_prefix = | ATC_suffix = | PubChem = 11764719 | DrugBank = | UNII = 87GWG91S09 | KEGG = D10925 | synonyms = H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2; D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide | C=32|H=49|N=9|O=5 | StdInChIKey = SFVLTCAESLKEHH-WKAQUBQDSA-N | StdInChI=1S/C32H49N9O5/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38)/t24-,25+,26+,27+/m1/s1 }}Elamipretide (also known as SS-31, , MTP-131 and Bendavia)[1][2] is a small mitochondrially-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that appears to reduce the production of toxic reactive oxygen species and stabilize cardiolipin.[3] Stealth Peptides, a privately held company, was founded in 2006 to develop intellectual property licensed from several universities including elamipretide; it subsequently changed its name to Stealth BioTherapeutics.[4][5] As of November 2017 Stealth had obtained an orphan designation in the US for use in mitochondrial myopathy and had started a Phase III trial in that indication.[2] References1. ^{{cite journal|title=Recommended INN List 75|journal=WHO Drug Information|date=2016|volume=30|issue=1|page=111|url=http://www.who.int/medicines/publications/druginformation/innlists/RL75.pdf}} 2. ^1 {{cite web|title=Elamipretide|url=http://adisinsight.springer.com/drugs/800032135|publisher=AdisInsight|accessdate=29 November 2017|language=en}} 3. ^{{cite journal|last1=Kloner|first1=RA|last2=Shi|first2=J|last3=Dai|first3=W|title=New therapies for reducing post-myocardial left ventricular remodeling.|journal=Annals of Translational Medicine|date=February 2015|volume=3|issue=2|pages=20|pmid=25738140|pmc=4322169|doi=10.3978/j.issn.2305-5839.2015.01.13}} 4. ^{{cite news|last1=Valigra|first1=Lori|title=Stealth Peptides sees positive results from Bendavia|url=http://www.bizjournals.com/boston/blog/mass-high-tech/2012/04/stealth-peptides-sees-positive-results-from.html|work=Boston Business Journal|date=April 9, 2012}} 5. ^{{cite news|last1=Dolgin|first1=Elie|title=New drugs offer hope for mitochondrial disease|url=https://www.statnews.com/2016/02/11/mitochondrial-disease-therapies/|work=STAT|date=11 February 2016}} 2 : Peptides|Experimental drugs |
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