| 词条 | Enterobacteria greA leader |
| 释义 |
| Name = Enterobacteria greA leader | image = Enterobacteria_greA_leader.png | width = | caption = Conserved secondary structure of greA leader, colours represent the fraction of canonical base pairs | Symbol = greA_leader | AltSymbols = | Rfam = RF01769 | RNA_type = Cis-reg; leader | Tax_domain = Enterobacteriales }} The Enterobacteria greA leader is a putative attenuator element identified by bioinformatics within bacteria of the γ-proteobacterial Enterobacteriales order.[1] It is located upstream of the rnk gene, encoding a transcription elongation factor, and presents a Rho-independent terminator at the 3' end. This RNA is presumed to operate as a non-coding leader, which regulatory mechanism remains to be elucidated.[1] The short abortive form of the greA transcript may also play a role as an independent sRNA: Potrykus et al. have shown that its overexpression leads to the repression of several genes.[2] The motif might be related to other rnk leaders such as the Pseudomonas rnk leader and the Enterobacteria rnk leader.[1] See also
References1. ^1 2 {{cite journal|last=Naville|first=M|author2=Gautheret, D|title=Premature terminator analysis sheds light on a hidden world of bacterial transcriptional attenuation.|journal=Genome Biology|year=2010|volume=11|issue=9|pages=R97|pmid=20920266|doi=10.1186/gb-2010-11-9-r97|pmc=2965389}} 2. ^{{cite journal|last=Potrykus|first=K|author2=Murphy, H |author3=Chen, X |author4=Epstein, JA |author5=Cashel, M |title=Imprecise transcription termination within Escherichia coli greA leader gives rise to an array of short transcripts, GraL.|journal=Nucleic Acids Research|date=Mar 2010|volume=38|issue=5|pages=1636–51|pmid=20008510|doi=10.1093/nar/gkp1150|pmc=2836576}} External links
1 : Cis-regulatory RNA elements |
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