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词条 Enzybiotics
释义

  1. Phage-derived enzymes

  2. See also

  3. References

Enzybiotics are an experimental antibiotic approach employing enzymes to combat pathogenic bacterial infections. The name is a combination of the words "enzyme" and "antibiotics" first coined in March 2001 by Nelson et al.[1] Many of the enzymes used as enzybiotics are lysins, enzymes derived from bacterial viruses (or bacteriophages) used to release progeny bacteriophage from infected bacteria, though other natural or synthetic enzymes may be used.[2][3]

Phage-derived enzymes

Enzybiotic approaches have attempted to incorporate bacteriophage-derived lysins to kill bacterial cells.[4][5] One particular lysin, isolated from phage P68 of Staphylococcus aureus, has shown antimicrobial activity against its host species when used along with the antibiotic gentamicin.[6]

See also

  • Phage therapy

References

1. ^{{cite journal|last=Nelson,|first=D |author2=Loomis, L |author3=Fischetti, VA|title=Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme.|journal=Proceedings of the National Academy of Sciences|date=March 2001|volume=98|issue=7|pages=4107–12|doi=10.1073/pnas.061038398|pmc=31187|pmid=11259652}}
2. ^{{cite journal|last=Veiga-Crespo|first=P|author2=Ageitos, JM |author3=Poza, M |author4= Villa, TG |title=Enzybiotics: a look to the future, recalling the past.|journal=Journal of Pharmaceutical Sciences|date=August 2007|volume=96|issue=8|pages=1917–24|pmid=17518365|doi=10.1002/jps.20853}}
3. ^Veiga-Crespo, P. and Villa, T. G. (2009) Phylogeny of Enzybiotics, in Enzybiotics: Antibiotic Enzymes as Drugs and Therapeutics (eds T. G. Villa and P. Veiga-Crespo), John Wiley & Sons, Inc., Hoboken, NJ, USA. {{DOI|10.1002/9780470570548.ch4}}
4. ^{{cite journal|last=Hermoso|first=JA|author2=García, JL |author3=García, P |title=Taking aim on bacterial pathogens: from phage therapy to enzybiotics.|journal=Current Opinion in Microbiology|date=October 2007|volume=10|issue=5|pages=461–72|pmid=17904412|doi=10.1016/j.mib.2007.08.002}}
5. ^{{cite journal|last=Pastagia|first=M|author2=Schuch, R |author3=Fischetti, VA |author4= Huang, D. |title=Lysins: the arrival of pathogen-directed anti-infectives.|journal=Journal of Medical Microbiology|date=October 2013|pages=1506–15|doi =10.1099/jmm.0.061028-0 |volume=62}}
6. ^{{cite journal|last=Manoharadas|first=S|author2=Witte, A |author3=Bläsi, U |title=Antimicrobial activity of a chimeric enzybiotic towards Staphylococcus aureus.|journal=Journal of Biotechnology|date=2009-01-01|volume=139|issue=1|pages=118–23|pmid=18940209|doi=10.1016/j.jbiotec.2008.09.003}}
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1 : Antibiotics
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