| 词条 | Eprobemide |
| 释义 |
| drug_name = | IUPAC_name = 4-Chloro-N-[3-(4-morpholinyl)propyl]benzamide | image = Eprobemide.svg | alt = | caption = | tradename = Befol (RU) | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration = Oral | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 87940-60-1 | ATCvet = | ATC_prefix = | ATC_suffix = | PubChem = 65659 | DrugBank = | ChEMBL = 2104298 | synonyms = Befol | ChemSpiderID = 59094 | C=14 | H=19 | Cl=1 | N=2 | O=2 | molecular_weight = 282.77 g/mol | smiles = C1COCCN1CCCNC(=O)C2=CC=C(C=C2)Cl | StdInChI = 1S/C14H19ClN2O2/c15-13-4-2-12(3-5-13)14(18)16-6-1-7-17-8-10-19-11-9-17/h2-5H,1,6-11H2,(H,16,18) | StdInChIKey = YYFGRAGNYHYWEZ-UHFFFAOYSA-N }}Eprobemide (INN) is a pharmaceutical drug that was used as an antidepressant in Russia (under the brand name Бефол/Befol).[1] It is a non-competitive reversible inhibitor of monoamine oxidase A[2][3] that exhibits selective action on serotonin deamination.[4] Eprobemide differs from moclobemide only in linker that connects morpholine fragment with chlorobenzamide—moclobemide has two carbon atoms while eprobemide has three. Its registration was cancelled on December 30, 2003.[5] References1. ^{{cite book | title = Dictionary of Pharmacological Agents | volume = 3 | author = C.R. Ganellin, David J. Triggle | page = 811 | year = 1996 | isbn = 978-0412466304}} {{Antidepressants}}{{Monoamine metabolism modulators}}{{nervous-system-drug-stub}}2. ^{{cite journal | pmid = 2054504 | year = 1991 | last1 = Gol'dina | first1 = O.A. | last2 = Moskvitina | first2 = T.A. | last3 = Gankina | first3 = E.M. | last4 = Kirkel' | first4 = A.Z. | last5 = Kamyshanskaia | first5 = N.S. | last6 = Lopatina | first6 = K.I. | last7 = Sokolova | first7 = T.V. | last8 = Zagorevskiĭ | first8 = V.A. | last9 = Val'dman | first9 = A.V. | last10 = Gorkin | first10 = V.Z. | title = The action of befol and its derivatives on monoamine oxidase of different origins | volume = 111 | issue = 3 | pages = 279–280 | journal = Biulleten' Eksperimental'noi Biologii I Meditsiny}} 3. ^{{cite journal | last1=Donskaya | first1=N.S. | last2=Antonkina | first2 = O.A. | last3 = Glukhan | first3 = E. N. | last4 = Smirnov | first4 = S. K. | title = Antidepressant Befol Synthesized Via Interaction of 4-Chloro-N-(3-chloropropyl)benzamide with Morpholine|journal=Pharmaceutical Chemistry Journal | date=2004-07-01 | volume=38 | series=0091-150X | issue=7 | pages=381–384 | doi=10.1023/B:PHAC.0000048439.38383.5f }} 4. ^Eprobemide, ChemIDplus 5. ^{{cite web|title=Befol — 4DOKTOR.RU Drug Information Handbook|url=http://www.4doktor.ru/default.aspx?drugid=35741|accessdate=4 February 2014|language=Russian}} 7 : Reversible inhibitors of MAO-A|Monoamine oxidase inhibitors|Antidepressants|Morpholines|Benzamides|Chloroarenes|Russian drugs |
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