| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Endoplasmic reticulum aminopeptidase 2 is a protein that in humans is encoded by the ERAP2 gene.[1] Function Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2).[2] References 1. ^{{cite web | title = Entrez Gene: Endoplasmic reticulum amino peptidase 2 | url = https://www.ncbi.nlm.nih.gov/gene/64167 }}
2. ^{{cite journal | vauthors = Tanioka T, Hattori A, Masuda S, Nomura Y, Nakayama H, Mizutani S, Tsujimoto M | title = Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases | journal = The Journal of Biological Chemistry | volume = 278 | issue = 34 | date = Aug 2003 | pmid = 12799365 | doi = 10.1074/jbc.M305076200 | pages=32275–83}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG | title = Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 26 | date = Dec 2001 | pmid = 11752456 | doi = 10.1073/pnas.241522398 | pmc=64988 | pages=15089–15094}}
- {{cite journal | vauthors = Hill LD, Hilliard DD, York TP, Srinivas S, Kusanovic JP, Gomez R, Elovitz MA, Romero R, Strauss JF | title = Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study | journal = BMC Medical Genetics | volume = 12 | pmid = 21569342 | doi = 10.1186/1471-2350-12-64 | pmc=3103419 | pages=64}}
- {{cite journal | vauthors = Ascher DB, Polekhina G, Parker MW | title = Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2 | journal = Acta Crystallographica Section F | volume = 68 | issue = Pt 4 | date = Apr 2012 | pmid = 22505422 | doi = 10.1107/S1744309112006963 | pmc=3325822 | pages=468–471}}
- {{cite journal | vauthors = Kamphausen E, Kellert C, Abbas T, Akkad N, Tenzer S, Pawelec G, Schild H, van Endert P, Seliger B | title = Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma | journal = Cancer Immunology, Immunotherapy | volume = 59 | issue = 8 | date = Aug 2010 | pmid = 20419298 | doi = 10.1007/s00262-010-0856-7 | pages=1273–84}}
- {{cite journal | vauthors = Stratikos E, Stern LJ | title = Antigenic peptide trimming by ER aminopeptidases--insights from structural studies | journal = Molecular Immunology | volume = 55 | issue = 3-4 | date = Oct 2013 | pmid = 23545452 | doi = 10.1016/j.molimm.2013.03.002 | pmc=3657621 | pages=212–219}}
- {{cite journal | vauthors = Bjornsson HT, Albert TJ, Ladd-Acosta CM, Green RD, Rongione MA, Middle CM, Irizarry RA, Broman KW, Feinberg AP | title = SNP-specific array-based allele-specific expression analysis | journal = Genome Research | volume = 18 | issue = 5 | date = May 2008 | pmid = 18369178 | doi = 10.1101/gr.073254.107 | pmc=2336807 | pages=771–779}}
- {{cite journal | vauthors = Mason CC, Hanson RL, Ossowski V, Bian L, Baier LJ, Krakoff J, Bogardus C | title = Bimodal distribution of RNA expression levels in human skeletal muscle tissue | journal = BMC Genomics | volume = 12 | pmid = 21299892 | doi = 10.1186/1471-2164-12-98 | pmc=3044673 | pages=98}}
- {{cite journal | vauthors = Haroon N, Tsui FW, Chiu B, Tsui HW, Inman RD | title = Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms | journal = The Journal of Rheumatology | volume = 37 | issue = 9 | date = Sep 2010 | pmid = 20595269 | doi = 10.3899/jrheum.100019 | pages=1907–10}}
- {{cite journal | vauthors = Qu HQ, Marchand L, Fréchette R, Bacot F, Lu Y, Polychronakos C | title = No association of type 1 diabetes with a functional polymorphism of the LRAP gene | journal = Molecular Immunology | volume = 44 | issue = 8 | date = Mar 2007 | pmid = 17129607 | doi = 10.1016/j.molimm.2006.10.015 | pages=2135–8}}
{{refend}}{{NLM content}}{{gene-5-stub}} 1 : Genes on human chromosome 5 |